The invention provides a central air conditioner fresh air purification device. The device comprises a purification box, an air inlet pipe, a fresh air outlet pipe, a first hollowed-out plate, a second hollowed-out plate, a partition plate, an adjustable locking fixing base structure, a rotatable lifting filter frame cover structure, an impingement drying frame structure, an observable drawing cleaning box structure, a U-shaped sliding rail, a first fixing cover, a second fixing cover, a primary filter, a negative ion generator, an electrostatic dust collector, an fresh air fan and an efficient filter. Through arrangement of a first sealing cover, a rotating rod, a pushing rod, a first filter screen, an L-shaped sliding rod, a threaded fixing pipe and the purification box, the pushing rodcan be grasped to rotate during working, and through threaded connection of the rotating rod and the threaded fixing pipe, the first sealing cover drives the first filter screen to move upwards, the first filter screen can be cleaned and replaced conveniently in the using process, and meanwhile lifting work is achieved.