The invention discloses a regulation method of an amorphous alloy average atomic cluster size. The regulation method of the amorphous alloy average atomic cluster size comprises the steps that amorphous alloy fused mass average atomic cluster size is calculated, specifically, the average atomic cluster sizes of amorphous alloy fused mass are calculated under different temperatures, the calculationresults of the average atomic cluster size changed with the temperature are acquired; super heating treatment is conducted on the alloy fused mass, specifically, the needed average atomic cluster size is chosen according to the calculation results, the temperature corresponding to the chosen average atomic cluster size is determined to be the super heating treatment temperature of the alloy fusedmass, heat preservation is conducted on the alloy fused mass under the super heating treatment temperature, and the alloy fused mass after the super heating treatment is acquired; and rapid solidification is conducted, specifically, the rapid solidification is conducted on the amorphous alloy fused mass after the super heating treatment, and an amorphous solid alloy is acquired. According to theregulation method of the amorphous alloy average atomic cluster size, a novel concept and a novel method of designing and preparation of an amorphous alloy microstructure are initiated, and the regulation method of the amorphous alloy average atomic cluster size has the characteristics of simpleness, convenience, high efficiency, low cost, high technology reliability and the like.