The invention relates to a detection method of a spiral case welding seam. The TOFD detection verification method of a large-scale spiral case welding seam comprises the following steps: step one, preparing a sample, determining spiral case defect acceptance standards and TOFD detection technological parameters; step two, performing a spiral case welding seam contrast test in which TOFD, UT and RT are performed respectively, that is, firstly performing TOFD, then performing UT and RT respectively after detection, and finally dissecting unqualified defects determined respectively so as to verify respective detection accuracy; step three, performing a welding test plate contrast test, that is, preparing welding defects of cracks, incomplete fusion, lack of penetration, dense pores, slag inclusion, and the like on a test plate, and performing a contrast test with reference to step two; step four, performing contrast test analysis, and verifying TOFD reliability according to the defect detection rates of the three methods. The invention forms a TOFD, RT, and UT contrast test method of large-scale spiral case welding seams, and can be successfully applied to the detection of power station unit spiral case on-site installation welding seams.