The minimally invasive sampling device comprises a sampling head, the sampling head comprises a first shell and a second shell, the first shell and the second shell are arranged to be of the same shape, one end of the first shell and one end of the second shell are arranged to be of a hemispherical structure, and the first shell and the second shell are arranged to be of a hollow structure; a blade outlet groove is formed between one end of the first shell and one end of the second shell; connecting rods are fixedly connected to the sides, close to each other, of the first shell and the second shell, a rotating rod is fixedly connected between the outer sides of the two connecting rods, torsional springs are connected to the outer sides of the connecting rods and located in the rotating rod, a
cutting knife is fixedly connected to the outer side of the rotating rod, and the
cutting knife is of an arc-shaped structure and is eccentrically connected with the rotating rod. Compared with a traditional
capsule-shaped clamping sampling device, the device has the advantages that the area of a sampled sample is larger, a wound is narrower, and the
recovery speed can be higher. Therefore, the effective examination area can be increased, the discomfort of a patient can be effectively reduced, the risk of
wound infection is reduced, and the healing process of a wound is accelerated.