41results about How to "Reduce or eliminate toxic side effects" patented technology

The invention relates to a preparation method of a drug carried microsphere capable of being positioning injected into a tumor cavity. When in a reaction process, the nano drug carried microsphere is prepared through a nano precipitation method by adopting polylactic acid as a carrier of an anti-cancer drug taxol and adopting bovine serum albumin as surfactant. Under an opsonic action of a reticuloendothelial system, after the drug is packed by polymer, the pharmacokinetic behaviors of the drug in vivo are always changed. The nano microsphere can be prepared into a slow-releasing preparation so that the half life of the drug in vivo is changed and the drug action time is prolonged; therefore, on condition of ensuring the drug effect, the dosage of the drug is reduced, and adverse effects are reduced or eliminated. Synchronously, the BSA (Bovine Serum Albumin) is served as external water phase to prepare polylactide particles, the bovine serum albumin can be absorbed on the surface of the microspheres so as to be easy to be identified by the reticuloendothelial system and absorbed by liver, therefore, the drug carried microspheres are gathered at the liver, the drug is slowly released at the liver, and the action time of the drug is prolonged.

The invention discloses a traditional Chinese medicine preparation for treating rheumatism and rheumatoid arthritis and a preparation method of the traditional Chinese medicine preparation for treating rheumatism and rheumatoid arthritis. The traditional Chinese medicine preparation is mainly prepared from radix clematidis, herba geranii, poria cocos, radix rehmanniae preparata, rhizoma pinelliae,radix saposhnikoviae, herba lycopodii, radix glycyrrhizae, radix angelicae pubescentis, rhizoma et radix notopterygii, radix gentianae macrophyllae, rhizoma ligustici wallichii, radix achyranthis bidentatae, ramulus cinnamomi, caulis spatholobi, radix notoginseng, radix aconiti, rhizoma dioscoreae nipponicae and ramulus euonymi. The traditional Chinese medicine preparation is safe, reliable, freeof allergic reaction, quick in absorption, quick in action, high in stability and effective in treatment of rheumatism and rheumatoid arthritis.

The invention discloses a traditional Chinese medicine preparation for treating hyperthyroidism. The traditional Chinese medicine preparation disclosed by the invention is prepared from the following medicinal materials in weight: 10 g of felwort, 10 g of cortex phellodendri, 10 g of raw arisaema consanguineum schott, 25 g of selfheal, 25 g of air potato, 25 g of yellow myrobalan peel, 5 g of semen sojae germinatum, 15 g of Lobaria retigera, 15 g of oriental blechnum frond, 15 g of rhizoma anemarrhenae, 8 g of radix bupleuri, 20 g of halogen alkaline, 8 g of dracocephalum heterophyllum, and 5 g of pig's thyroid gland. Found from clinical experiments, the obvious effect of effectively treating hyperthyroidism is achieved by selecting proper medicinal materials and a mixture ratio thereof; and furthermore, the traditional Chinese medicine preparation disclosed by the invention is safe and free from toxic and side effect.

The invention discloses a traditional Chinese medicine for treating sepsis. The traditional Chinese medicine is prepared from the following medicinal materials in parts by weight: 10 parts of rattletop, 15 parts of root of common peony, 10 parts of the root bark of the peony tree, 30 parts of honeysuckle flower, 15 parts of fructus forsythiae, 10 parts of red halloysite, 6 parts of raw rhubarb, 10 parts of Scutellaria baicalensis, 5 parts of Coptis chinensis, 8 parts of Commiphora mukul, 5 parts of patrinia, 10 parts of Radix Ophiopogonis, 5 parts of short-tube lycoris, 6 parts of the root of bidentate achyranthes, 5 parts of Mirabilis himalaica and 3 parts of Pouzolzia elegans. The clinical experiment proves that proper medicinal materials and ratios thereof are selected, the obvious effect of effectively treating the sepsis is achieved, and the traditional Chinese medicine is safe and does not have any toxic or side effect.

The invention discloses a traditional Chinese medicine decoction for treating cerebral infarction. The decoction is prepared from traditional Chinese medicinal materials in parts by weight as follows: 20 parts of white peony roots, 20 parts of calamus, 15 parts of round-root dutohmanspipe fruits, 10 parts of leeches, 12 parts of stiff silkworms, 10 parts of Chinese angelica, 8 parts of Teucrium viscidum, 12 parts of Syringa pinnatifolia, 4 parts of Pileostegia viburnoides, 12 parts of borneol, 4 parts of copperleaf herbs, 6 parts of all-grass of shore podgrass, 5 parts of Citrullus colocynthis, 5 parts of Sapium baccatum, 6 parts of wild jack beans, 6 parts of aizoon stonecrop herbs, 6 parts of snakegourd roots, 4 parts of Chinese thorowax roots, 4 parts of oysters, 14 parts of milkvetch roots, 6 parts of Halenia elliptica, 5 parts of Disporum cantoniense, 4 parts of flowers of Mesua ferrea, 3 parts of photinia stems, 3 parts of Indian mock strawberries and 2 parts of ginkgo pollen. Clinical experiments prove that through selection of the proper medicinal materials and ratio of the medicinal materials, the decoction has the significant effect in treating the cerebral infarction and is safe and free of toxic and side effects.

The invention discloses Yang-invigorating coffee for the male and a preparation method thereof, and belongs to the technical field of beverage preparation. The Yang-invigorating coffee for the male comprises the following raw materials: Colombian coffee beans, epimedium herb, eurycoma longifolia, Chinese dodder seeds, cortex eucommiae, radix polygoni multiflori, fenugreek, radix polygonati officinalis, mulberry fruits, ligusticum chuanxiong, raw radix rehmanniae, radix platycodonis, and black Chinese wolfberry fruits; and the Yang-invigorating coffee for the male is prepared by the following steps of carrying out decocting, carrying out concentrating, carrying out membrane filtration, carrying out decolorizing, carrying out sterilization and so on. According to the Yang-invigorating coffeefor the male, the raw radix rehmanniae, the radix platycodonis and the black Chinese wolfberry fruits are adopted as a reinforcement system; and thus, Yang-invigorating effects and flavor of the Yang-invigorating coffee are improved.

The invention discloses a traditional Chinese medicine capsule for treating sciatica. The traditional Chinese medicine capsule is prepared from the following medicinal materials in parts by weight: 30 parts of astragalus, 30 parts of dandelion pollen, 15 parts of milk peaches, 15 parts of salvia miltiorrhiza, 15 parts of roasted myrrh, 10 parts of radix achyranthis bidentatae, 10 parts of radix angelicae pubescentis, 10 parts of roasted olibanum, 10 parts of earthworms, 8 parts of medicinal flared roots, 4 parts of heartleaf saussurea roots, 5 parts of smallage seeds and 8 parts of mango stones. Clinical experiments prove that the remarkable effect on treating sciatica is achieved through selecting proper medicinal materials and the ratio of the medicinal materials; and the traditional Chinese medicine capsule is safe and free of toxic or side effect.

The invention discloses a nano microcapsule for six ingredients with rehmannia and a preparation process thereof. The preparation process comprises the following steps of: taking the traditional pills for six ingredients with the rehmannia as a basis, adopting a multilevel dynamic hot reflux method for extraction and concentration of radix rehmanniae preparata, Poria cocos and rhizoma alismatis; carrying out nano-level crushing on dogwood, tree peony bark and yam; and uniformly mixing the nano fine powder and concentrated liquor according to certain proportion, carrying out freezing or spray-drying treatment, preparing the nano microcapsule, and finally adopting a corresponding preparation technology to prepare into a dosage form applicable on clinic. The process has the advantages of simple operation, short process flow, easy control of parameters, low cost, no toxic and side effects caused by organic reagents and the like. The nano microcapsule for six ingredients with the rehmannia can be directly used, and also can be used as a drug intermediate. In the nano microcapsule, the drug effect can be obviously delayed, the administration times and amount can be reduced, and the toxic and side effect caused by the traditional drug is reduced or eliminated. The nano microcapsule is concentrated by more than three times compared with the existing nano microcapsule product for six ingredients with the rehmannia on the market, and the total daily dosage can be reduced by 3-6 times compared with the traditional products such as the concentrated six ingredients with the rehmannia and the like.

The invention discloses a traditional Chinese medicine capsule for treating prosopalgia. The traditional Chinese medicine capsule is characterized by being prepared from the following medicinal materials in parts by weight: 8-10 parts of Szechuan lovage rhizome, 8-10 parts of ipomoea purga hayne, 8-10 parts of scandent schefflera stem and leaf, 8-10 parts of incised notopterygium, 8-10 parts of dahurian angelica root, 8-3 parts of salt alkali, 8-10 parts of scorpion, 13-15 parts of centipede, 5-6 parts of wild mint, 5-6 parts of licorice root, 3-4 parts of salt alkali, 8-10 parts of corylus avellana, 0-5 parts of snow frog fat and 0-5 parts of rhizome of giant typhonium. A clinical experiment proves that by selecting appropriate medicinal materials and proportions, the traditional Chinese medicine capsule disclosed by the invention can achieve a significant effect of treating the prosopalgia, is definite in effect and short in cure time, is safe, and does not have toxic and side effects.

The invention discloses traditional Chinese medicine decoction for treating chronic superficial gastritis. The traditional Chinese medicine decoction is prepared from the following traditional Chinese medicinal materials in weight proportion: 15 parts of amomum aurantiacum, 8 parts of balaps japanensis yunnanensis mars, 4 parts of rhizoma coptidis, 12 parts of taraxacum mongolicum, 8 parts of radix salviae miltiorrhizae, 8 parts of rhizoma corydalis, 12 parts of radix paeoniae alba, 6 parts of liquorice, 6 parts of rhizoma atractylodis macrocephalae, 6 parts of fructus aurantii, 5 parts of radix aucklandiae, 6 parts of crystal soda, 5 parts of marsdenia tenacissima, 4 parts of morus nigra, 4 parts of rheum officinale, 5 parts of bark of terminalia chebula, 4 parts of spondias pinnata, 4 parts of ziziphus mauritiana, 5 parts of diospyros kaki silvestris, 6 parts of aizoon stonecrop herb and 4 parts of leaves of Chinese ilex. Clinical experiment results prove that through selecting the proper traditional Chinese medicinal materials according to the ratio, the decoction has the remarkable efficacy for treating chronic superficial gastritis, and is safe and free of toxic and side effect.

The invention discloses traditional Chinese medicine capsules for treating nocturia. The capsules are prepared from traditional Chinese medicinal materials in parts by weight as follows: 10 parts of Chinese yams, 7 parts of prepared rehmannia roots, 4 parts of oriental waterplantain rhizomes, 5 parts of tree peony bark, 1.5 parts of cassia bark, 6 parts of all-grass of bulley herminium, 9 parts of prepared common monkshood daughter roots, 6 parts of palmleaf raspberry fruits, 5 parts of semiaquilegia seeds, 4 parts of Borassus flabellifer, 3 parts of rhubarb, 6 parts of smallage seeds, 3 parts of Commiphora mukul, 4 parts of willow leaves, 6 parts of piptostegia roots and 9 parts of semen lepidii. Clinical experiments prove that through selection of the proper medicinal materials and ratio of the medicinal materials, the capsules have the significant effect of treating the nocturia and are safe and free of toxic and side effects.

The invention discloses a plant essence peptide composition for promoting wound healing. The plant essence peptide composition comprises, by weight, 55 parts of tragus berteronianus, 12 parts of cuttlebone, 11 parts of Chinese holly leaves, 18 parts of common bletilla pseudobulb, 20 parts of hibiscus syriacus flowers, 10 parts of honeycomb, 9 parts of rhizoma polygoni cuspidati, 12 parts of Japanese ophiorrhiza herbs, 10 parts of Huangmai lindera glauca, 14 parts of medical stone, 9 parts of papaver rhoeas, 10 parts of Jinding erythrina corallodendron and trace epidermal growth factor stock solution. The plant essence peptide composition has the advantages that selected plants are appropriately compatible with one another; as proved by clinical application, the plant essence peptide composition is beneficial to wound healing, and the total effective rate can reach 98%; the plant essence peptide composition is safe, is free of toxic and side effects and is worthy of being widely applied to promoting wound healing, and accordingly scar formation can be reduced.

The invention discloses a traditional Chinese medicine for treating hyperosteogeny arthritis. The traditional Chinese medicine is prepared from the following medicinal materials by weight: 10g of pubescent angelica root, 15g of mistletoe, 10g of large-leaf gentian root, 10g of eucommia bark, 10g of angelica sinensis, 10g of radix paeoniae alba, 10g of coix lachryma-jobi, 10g of Chuanxiong rhizome, 10g of cinnamon, 3g of amomum aurantiacum, 8g of Chinese milk vetch pollen, 5g of schefflera arboricola hayata, 8g of brine alkali and 4g of breynia fruticosa. Proved by clinical trials, through selecting appropriate medicinal materials and a proportioning ratio thereof, the traditional Chinese medicine achieves a remarkable effect on the treatment of hyperosteogeny arthritis, is safe and is free from toxic or side effects.

The invention discloses a traditional Chinese medicine enema for treating severe acute pancreatitis. The enema is prepared from the following traditional Chinese medicinal materials in parts by weight: 10 parts of silene jenisseensis willd, 8 parts of radix paeoniae alba, 12 parts of fructus aurantii immaturus, 18 parts of radix scutellariae, 12 parts of cortex magnoliae officinalis, 25 parts of purple flower holly leaves, 10 parts of radix glycyrrhizae, 10 parts of yellow soybeans, 10 parts of common crabgrass herb, 13 parts of raw rhubarb, 15 parts of herb of diversifolious gueldenstaedtia, 12 parts of dandelion, 8 parts of thevetia peruviana, 6 parts of hydrocotyle sibthorpioides, 8 parts of hydnocarpus annamensis, 4 parts of wild cumin, 6 parts of erigeron breviscapus, 6 parts of triglochin martimum, 5 parts of ipomoea purga hayne roots, 5 parts of sapium baccatum roots, 6 parts of wild semen canavaliae, 6 parts of aizoon stonecrop herb and 6 parts of radix trichosanthis. Proved by clinical experiments, through the selection of appropriate medicinal materials and proportion thereof, the enema achieves the remarkable efficacy of treating severe acute pancreatitis, and is safe and free of toxic and side effects.

The invention discloses traditional Chinese medicine capsules for preventing and treating senile psychosis. The traditional Chinese medicine capsules are prepared from the following traditional Chinese medicinal materials in parts by weight: 20 parts of prepared rehmannia root, 15 parts of rhizome of acorus calamus, 10 parts of radix polygoni multiflori, 25 parts of the root of red-rooted salvia, 10 parts of szechuan lovage rhizome, 12 parts of dried mature seeds of corylus avellana, 18 parts of dried mature fruit of citrullus colocynthis, 8 parts of forest frog's oviduct, 15 parts of pine pollen disruption powder, 8 parts of Chinese thorowax root, 8 parts of oyster, 18 parts of distilled liquid of rose, 12 parts of all-grass of digitaria sanguinalis, 8 parts of astragalus membranaceus, 12 parts of the fruit of Chinese wolfberry, 5 parts of dried mature fruit of cordia dichotoma, 5 parts of root of sapium baccatum, 6 parts of seeds and roots of wild sword bean, 6 parts of aizoon stonecrop herb and 4 parts of holly leaf. Clinical experiment results show that the remarkable efficacy of preventing and treating senile psychosis is realized by selecting proper medicinal materials according to the ratio and high safety and no toxic or side effects are realized.

The invention discloses traditional Chinese medicine decoction for preventing and treating senile dementia. The traditional Chinese medicine decoction is prepared from the following traditional Chinese medicinal materials in weight proportion: 20 parts of prepared rehmannia root, 15 parts of rhizome of acorus calamus, 10 parts of radix polygoni multiflori, 25 parts of the root of red-rooted salvia, 10 parts of vinegar-quenched tortoise shell, 12 parts of dried mature seeds of corylus avellana, 18 parts of dried mature fruit of citrullus colocynthis, 8 parts of resina liquidamberis, 15 parts of Mongolian snakegourd root, 8 parts of Chinese thorowax root, 8 parts of oyster, 18 parts of distilled liquid of rose, 12 parts of eel blood, 8 parts of astragalus membranaceus, 12 parts of the fruit of Chinese wolfberry, 5 parts of dried mature fruit of cordia dichotoma, 5 parts of root of sapium baccatum, 6 parts of seeds and roots of wild sword bean, 6 parts of aizoon stonecrop herb and 4 parts of holly leaf. Clinical experiment results show that the remarkable efficacy of preventing and treating senile dementia is realized by selecting proper medicinal materials according to the ratio and high safety and no toxic or side effects are realized.

The invention discloses a traditional Chinese medicine preparation for treating reflux esophagitis. The traditional Chinese medicine preparation is prepared from the following medicinal materials in parts by weight: 10 parts of tree peony root bark, 10 parts of cape jasmine, 10 parts of herb of resupinate woodbetony, 12 parts of white peony root, 6 parts of radix bupleuri, 10 parts of seed of squarrose agriophyllum, 10 parts of mirabilite, 3 parts of carbonized human hair, 15 parts of pennycress seed, 6 parts of tragacanth, 10 parts of skin on boiled milk, 10 parts of fleshy lysionotus, inula flower, 15 parts of halite, 15 parts of lalang grass rhizome and 10 parts of honeysuckle. Clinical experiments prove that the traditional Chinese medicine preparation for treating reflux esophagitis has excellent curative effect on the improvement of cardinal symptoms of the reflux esophagitis, the elimination of gastric juice reflux, the repair and protection of the esophagus mucosa, and the elimination of mucosal inflammation due to the appropriate selection of the medicinal materials and the proportions thereof, and as the medicine takes effect, the symptoms are lessened, and moreover, the traditional Chinese medicine preparation has good prevention effect on pathogenesis transmission and invasion into viscera and has a great value in clinical application.

The invention discloses a traditional Chinese medicine for treating gastrointestinal dysfunction caused by critical diseases. The traditional Chinese medicine is prepared from the following Chinese medicinal herbs in parts by weight: 5 parts of coptis roots, 2 parts of immature bitter oranges, 3 parts of officinal magnolia barks, 4 parts of medicinal evodia fruits, 5 parts of dried tangerine peels, 3 parts of all-grass of shore podgrass, 3 parts of solanum mammosum roots, 3 parts of skin on boiled milk, 3 parts of salt alkali, 4 parts of manyflower solomonseal rhizome, 3 parts of garlic and 4 parts of distilled liquid of rose. Clinical experiments show that the traditional Chinese medicine has a significant effect on relieving gastrointestinal dysfunction caused by critical diseases due to the combination of the selected suitable Chinese medical herbs at a proper ratio, and the traditional Chinese medicine is safe and has no side or toxic effect and can be also used for preventing related complications.

The invention provides an olanzapine-pamoate sustained-release microparticle preparation and a preparation method therefor. Sustained-release microparticles are prepared through encapsulating antischizophrenic drugs with high polymers, and the olanzapine-pamoate sustained-release microparticle preparation has the entrapment rate of 85%-95% and the particle size of 15 to 35 microns. According to the product provided by the invention, known toxic or side effects of the product are lowered or eliminated, sudden release of primary stage can be remarkably inhibited, the sustained-release cycle is prolonged, and the actions of lowering sudden release and prolonging sustained release can be obviously exerted. The compliance of mental illness sufferers is improved, and patients are not required tobe observed under professional medical conditions after medication.

The invention discloses a traditional Chinese medicine decoction for treating degenerative osteoarthritis. The traditional Chinese medicine decoction is prepared from the following traditional Chinese medicinal materials in parts by weight: 15 parts of radix rehmanniae preparata, 20 parts of lycium chinense, 18 parts of astragalus membranaceus, 12 parts of black pebbles, 8 parts of lagoecia cuminoidesL. Seeds, 10 parts of carthamus tinctorius, 12 parts of dorema ammoniacum, 6 parts of radix achyranthis bidentatae, 20 parts of tragacanth, 6 parts of arctium lappa, 6 parts of bombyx batryticatus, 25 parts of phlogacanthus curviflorus, 10 parts of gossypium herbaceum, 5 parts of sapium baccatum, 6 parts of cana valia virosa, 6 parts of sedum aizoon and 6 parts of radix trichosanthis. Clinical experiments show that through selecting appropriate herbs and a matching ratio, the traditional Chinese medicine decoction provided by the invention has remarkable curative effects on treating degenerative osteoarthritis, and is safe and free of toxic and side effects.

The invention discloses a traditional Chinese medicine decoction for treating trigeminal neuralgia. The traditional Chinese medicine decoction is prepared from 6 parts by weight of scorpion, 6 parts by weight of centipede, 12 parts by weight of aizoon stonecrop herb, 30 parts by weight of gypsum, 3 parts by weight of herba asari, 9 parts by weight of anemarrhena, 9 parts by weight of phlogacanthus curviflorus, 8 parts by weight of stiff silkworm, 10 parts by weight of seed of Lagoecia cuminoides, 6 parts by weight of diversifolious poplar resin, 5 parts by weight of Cordyceps hawkesii, 10 parts by weight of dry ginger, 5 parts by weight of Sapium baccatum, 6 parts by weight of wild sword bean, 6 parts by weight of aizoon stonecrop herb and 6 parts by weight of trichosanthes root. A clinical experiment proves that through selection of appropriate medicinal materials and a ratio, the traditional Chinese medicine decoction has substantial effects of treating acute pancreatitis, is safe and has no toxic or side effect.

The invention discloses a traditional Chinese medicine capsule for treating chronic bronchitis. The capsule is prepared from the following medicinal materials in parts by weight: 5 parts of nightshade, 10 parts of bighead atractylodes rhizome, 10 parts of gynostemma pentaphyllum, 5 parts of piperic, 10 parts of pinellia ternate, 10 parts of pericarpium citri reticulatae, 5 parts of citronella, 5 parts of cordia dichotoma fruits and 5 parts of papaver pollen. Clinical experiments verify that by selecting appropriate medicinal materials and proportion, the capsule has a remarkable effect of treating chronic bronchitis and is safe and free of toxic or side effects.

The invention discloses a traditional Chinese medicine for treating chronic gastritis. The traditional Chinese medicine is prepared from the following medicinal materials in parts by weight: 30 parts of fried astragalus membranaceus, 30 parts of wild celery seeds, 20 parts of medical stone, 10 parts of commiphora mukul, 20 parts of radix paeoniae alba, 6 parts of liquorice, 20 parts of sesame flower flour, 10 parts of nagkassar flower, 15 parts of common andrographis herb, 12 parts of blueflower cicerbita root and 10 parts of paleaceous knotweed rhizome. A clinical experiment proves that the significant efficacy of treating the chronic gastritis is achieved by selecting proper medicine materials at a proper ratio; and the traditional Chinese medicine is safe, and free of a toxic or side effect.

The invention discloses a traditional Chinese medicine capsule for treating apoplectic hemiplegia. The capsule is prepared from the following traditional Chinese medicinal materials in parts by weight: 20 parts of rhizoma atractylodis macrocephalae, 15 parts of rhizoma polygonati, 10 parts of radix aucklandiae, 12 parts of liquid distilled from jasmine flowers, 12 parts of levant cotton roots, 10 parts of sapium baccatum roots, 10 parts of radix paeoniae rubra, 6 parts of radix burpleuri, 6 parts of oysters, 8 parts of dried black soybean sprouts, 8 parts of pyrethrum cinerariifolium roots, 6 parts of mesua ferrea flowers, 5 parts of sandalwood oil, 5 parts of sapium baccatum roots, 6 parts of wild semen canavaliae, 6 parts of aizoon stonecrop herb and 6 parts of pine pollen disruption powder. Proved by clinical experiments, through the selection of appropriate medicinal materials and proportion thereof, the capsule achieves the remarkable efficacy of treating apoplectic hemiplegia, and is safe and free of toxic and side effects.