The invention provides a slope support construction method combined with a building main body structure. The method comprises the following steps of leveling a site, excavating a construction working surface of a bottom plate of a retaining wall, building the bottom plate, a wall body and a bearing platform of the retaining wall, carrying out primary backfilling, reserving a first platform on the wall top of the retaining wall, building a foundation pipe pile of a building main body structure, performing secondary backfilling, reserving a second platform, constructing a main body foundation pipe pile, a bearing platform and an overhead structure column of the platform, performing third backfilling, reserving a third platform, constructing a main body foundation pipe pile, a bearing platform and an overhead structure column of the platform, performing final backfilling, flattening, constructing main body foundation pipe piles and finishing slope support. By flexibly adopting a combined form of vertical support and step-slope support with different heights, the building main body structure is overhead for graded step-slope, so that the aims of reducing the vertical support height, reducing the risk of an ultrahigh retaining wall, reducing the earthwork backfilling amount and saving the construction cost are fulfilled.