The invention provides intelligence-improving brain-nourishing trichosanthis seed oil. The oil is prepared from the following raw materials in parts by weight: 280-300 parts of kernels of juglans cathayensis dode, 100-120 parts of trichosanthis seeds, 50-60 parts of ginseng, 50-60 parts of buckwheat, 100-120 parts of black sesame, 30-40 parts of large-leaved gentian, 30-40 parts of ligusticum wallichii, 30-40 parts of angelica sinensis, 30-40 parts of radix paeoniae alba, 40-50 parts of notopterygium root, 5-6 parts of asarum, 6-7 parts of saposhnicovia divaricata, 30-40 parts of scutellaria baicalensis, 30-40 parts of gypsum, 30-40 parts of radix angelicae, 30-40 parts of rhizoma atractylodis macrocephalae, 30-40 parts of white poria cocos, 30-40 parts of radix rehmanniae praeparata, 4-5 parts of radix angelicae pubescentis and the like, wherein the juglans cathayensis dode has the effects of nourishing brain; ginseng serving as a main auxiliary is used for tranquilizing and improving intelligence; large-leaved gentian is used for dispelling wind, removing cold, clearing and activating the channels and collaterals; notopterygium root, radix angelicae pubescentis, saposhnicovia divaricata, radix angelicae and asarum are used for dispelling wind, eliminating evil factors and expelling wind to dredge collaterals; ligusticum wallichii, angelica sinensis, radix paeoniae alba and radix rehmanniae praeparata are used for nourishing blood and promoting blood circulation, so that tendons are smooth due to sufficient blood, wind is easily dispelled due to dredged collaterals; rhizoma atractylodis macrocephalae and poria cocos are used for tonifying qi and strengthening spleen to generate qi and blood; and scutellaria baicalensis, gypsum and rehmannia have effects of clearing and purging stagnation heat and the like. Therefore, the trichosanthis seed oil has a certain health-care function, and can be used for improving intelligence, relieving mental fatigue and preventing hemiplegia and other diseases caused by hypertension and cerebral thrombosis if the trichosanthis seed oil is taken for a long time.