The invention belongs to the technical fields of grape products and a preparation method thereof, and particularly relates to a grape juice health-care beverage and a preparation method thereof. The grape juice health-care beverage is prepared from the following raw materials in parts by weight: 100-200 parts of grapes, 25-34 parts of semen cuscutae, 1-4 parts of licorice roots, 2-8 parts of Chinese wolfberry fruits, 3-9 parts of moldavica dragonhead, 2-8 parts of mulberries, 24-35 parts of anchusa italica, 4-15 parts of silkworm cocoons, 5-16 parts of lavender, 5-14 parts of radix salviae miltiorrhizae, 3-7 parts of red roses, 16-24 parts of ocimum gratissimum, and 11-19 parts of native gold. The grapes are used as a main material, and the semen cuscutae, the licorice roots, the Chinese wolfberry fruits, the moldavica dragonhead, the mulberries, the anchusa italica, the silkworm cocoons, the lavender, the radix salviae miltiorrhizae, the red roses, the ocimum gratissimum and the native gold are used as auxiliary materials, so that the made grape health-care beverage can nourish the liver and the kidney, invigorate the spleen, replenish qi, clear away the lung, relieve exterior syndromes, eliminate phlegm, relieve a cough, clear heat, remove toxicity, promote salivation and moisten dryness, and can achieve the effects of benefiting and stimulating brain nerves, promoting repairand regeneration of tissues, promoting immunization, maintaining beauty, keeping young, moistening skin and muscle, soothing tense mood, calming mental efforts, suppressing qi, conditioning blood andqi, and caring bodies.