The invention belongs to the field of textiles and provides a structure and a production method of a weft-knitted jacquard shoe upper material. According to the weft-knitted jacquard shoe upper material, terylen low-melting-point color filaments with skin-core structures are adopted, the meshes, esthetic appearance and air permeability of the shoe upper material are realized by utilizing air-layer jacquard tissues as fundamental tissues, loop accumulation tissues or loop transfer tissues on a dual-way jacquard dual-side loop transfer round weft machine; by virtue of cooperation between colors and structural jacquards, functional sections of the shoe upper material are realized; during aftertreatment, a skin layer is fused at a certain temperature under a certain pressure, so that dual-side weft-knitted jacquard shoe upper fabric loops are mutually glued, then cooled and solidified, so that the shoe upper material with appropriate rigidity and hand feeling is obtained; spandex can also be added, so that the elasticity and the density of the fabric are enhanced. The weft-knitted jacquard shoe upper material is variable in pattern, color and style, beautiful in appearance, portable and flexible, favorable in air permeability and comfort in wear; traditional working procedures of cutting, sewing, bonding and the like for shoe materials are not needed, so that the equipment investment and the labor cost are lowered.