The invention discloses a novel pesticide combination containing thiamethoxam, which is mainly characterized in that the combination contains active ingredients thiamethoxam and lambda-cyhalothrin and the balance of adjuvant, the weight ratio of the thiamethoxam to the lambda-cyhalothrin is 60:1 to 1:60, and the combination can be prepared into wettable powder, water dispersible granules, suspending agent, suspending emulsion, emulsion in water, microemulsion and microcapsule suspending agent. The novel pesticide combination disclosed by the invention has the advantages that the combination can be used for preventing and controlling various injurious insects, the synergistic effect is obvious, the insecticidal spectrum is expanded and the activity to injurious insects on rice, wheat, cotton, tea trees, tomatoes, corns, sugarcanes, potatoes, oranges, apples and cruciferous vegetables is higher; the combination has a slow release effect, the pesticide dosage is reduced, the combination is safe to human and livestock and does not have pesticide damage, and the environmental compatibility is good; and the adhesive force of preparations is enhanced, the preparations are resistant to rainwater washing, the efficacy lasts long, and the like.