Patents
Literature
Hiro is an intelligent assistant for R&D personnel, combined with Patent DNA, to facilitate innovative research.
Hiro

32 results about "ETHYLENEDIAMINE DERIVATIVES" patented technology

Ethylenediamine derivatives

The invention relates a compound represented by the formula (1):Q1-Q2-C(═O)—N(R1)-Q3-N(R2)-T1-Q4  (1)wherein R1 and R2 represent H or the like; Q1 represents an aromatic ring, heterocyclic ring or the like; Q2 represents a single bond, aromatic ring, heterocyclic ring or the like; Q3 represents a group or the like, Q4 represents an aromatic ring, heterocyclic ring or the like; and T1 represents —CO— or —SO2—, and a medicine which comprises the compound and is useful for thrombosis and embolism.
Owner:DAIICHI PHARMA CO LTD

Novel ethylenediamine derivatives

A compound represented by the following formula (1): Q1—Q2—To—N(R1)—Q3—N(R2)—T1—Q4  (1) [wherein, R1 and R2 are hydrogen atoms or the like; Q1 is a saturated or unsaturated, 5- or 6-membered cyclic hydrocarbon group which may have a substituent, or the like; Q2 is a single bond or the like; Q3 represents the following group: —C(R3a)(R4a)—{C(R3b)(R4b)}m1—{C(R3c)(R4c)}m2—{C(R3d)(R4d)}m3—{C(R3e)(R4e)}m4—C (R3f)(R4f)— (in which, R3a to R4e represent hydrogen or the like); T0 represents a carbonyl group or the like; and T1 represents —COCONR— or the like]; or salt thereof, solvate thereof, or N-oxide thereof. The compound is useful as a preventive and / or therapeutic agent for cerebral infarction, cerebral embolism, myocardial infarction, angina pectoris, pulmonary infarction, pulmonary embolism, Buerger's disease, deep venous thrombosis, disseminated intravascular coagulation syndrome, thrombus formation after valve or joint replacement, thrombus formation and reocclusion after angioplasty, systemic inflammatory response syndrome (SIRS), multiple organ dysfunction syndrome (MODS), thrombus formation during extracorporeal circulation, or blood clotting upon blood drawing.
Owner:DAIICHI PHARMA CO LTD

Copper Plating Solution And Copper Plating Method

The invention provides a copper plating solution. The copper plating solution includes: water-soluble copper salt; ethylenediamine; at least one of EDTA, a substituted derivative of EDTA, an ethylenediamine derivative, or glycine; and at least one of hydantoin or a substituted derivative thereof. The copper plating solution allows an aluminum or aluminum alloy base to be displacement-plated with copper.
Owner:C UYEMURA & CO LTD

Ethylenediamine derivatives

The invention relates a compound represented by the formula (1): Q1-Q2-C(═O)—N(R1)-Q3-N(R2)-T1-Q4  (1) wherein R1 and R2 represent H or the like; Q1 represents an aromatic ring, heterocyclic ring or the like; Q2 represents a single bond, aromatic ring, heterocyclic ring or the like; Q3 represents a group or the like, Q4 represents an aromatic ring, heterocyclic ring or the like; and T1 represents —CO— or —SO2—, and a medicine which comprises the compound and is useful for thrombosis and embolism.
Owner:DAIICHI PHARMA CO LTD

Preparing and application of a reactive mercury ion fluorescence probe

The invention discloses a reactive mercury ion fluorescent probe and a preparing method as well as application thereof. The method comprises the following steps: (1) 5-aminophenyl and 10, 15, 20- trisulfonate phenyl porphyrin (PNH2) is dissolved in distilled water to form solution of 7.5 mg / ml. The triphosgene is dissolved in dichloromethane to form solution of 5 MuL / mL. After the two is mixed at equal volume, react at room temperature for 3 to 5 hours and then purified, resulted to 5 -phenyl isothiocyanate base and 10, 15, 20 - trisulfate phenylporphyrin (PNCS); (2) 5 - phenyl isothiocyanate base and 10, 15, 20 - trisulfate phenylporphyrin (PNCS) and ethylenediamine derivatives are mixed in an equimolar ratio and dissolved in a mixed solvent of acetone and distilled water, to form a total concentration of 20 mg / mL solution. Finally, the solution reacts at room temperature for 6-10 hours, and after purification, the final product porphyrin-thiourea (PT) is obtained. The probe has good water solubility and shows high sensitivity and selectivity for mercury ions, and shows significant colors and fluorescence changes when detecting mercury ions. Combined with laser confocal scanning microtechnique, the probe can also be obtained the detecting imaging of the mercury ion within living cells.
Owner:ZHEJIANG UNIV CITY COLLEGE

Preparation method of N-substituted ethylene diamine derivative

The invention discloses a synthetic method of an N-substituted ethylene diamine derivative as structure fragments for various drugs. The method comprises the following steps: first performing Michael addition reaction on aromatic amine or fatty amine or heterocyclic amine and ethyl acrylate, then performing hydrazinolysis, and finally performing Curtius rearrangement reaction, thus preparing the target compound. The method has the advantages of low cost, moderate conditions, easy operation, high total yield and the like.
Owner:HEFEI UNIV OF TECH

Novel ethylene diamine derivative

The invention relates to ethylenediamine compounds of which the structural formula is as shown in a formula (I), pharmaceutically acceptable salts, a preparation method thereof and application of the ethylenediamine compounds in preparing medicines for treating infectious diseases caused by tubercle bacillus and particularly infectious diseases caused by multidrug resistant tubercle bacillus. The compounds of which the structural formula is shown in the (I) have good in vitro tubercle bacillus resistant activity and good in vivo pharmacokinetics property.
Owner:SHANGHAI SUN SAIL PHARMA SCI & TECH CO LTD

Synthetic method of ethylene diamine derivative

The invention discloses a synthetic method of an ethylene diamine derivative. The synthetic method comprises the following step of: reacting aziridine or an aziridine derivative (II) with an amine compound (III) in a solvent at the temperature of 40-400 DEG C and the gage pressure of 0-2.0 MPa under the catalysis of a catalyst to obtain the ethylene diamine derivative (I), wherein a reaction formula is as follows. According to the method, the reaction step is only one; the by-products are fewer; the selected catalyst is low in price, safe and nontoxic and can achieve very good catalysis effect; the solvent is low in price, is conveniently recovered under the precondition of ensuring the smooth progress of reaction and can be recycled, so that low synthetic cost is achieved.
Owner:TIANJIN UNIV

Pickling inhibitor and preparation method thereof

InactiveCN1804124AMany polar atomsImprove adsorption capacityHalogenCarboxylic acid
The preparation method for inhibitor used in convey-halogen pipe comprises: dissolving and mixing the material with amine salt, thiocyanic acid, ethanediamine derivative, surfactant, carboxylic acid and water; before using, adding surfactant and carboxylic acid, stirring evenly, and adjusting proper concentration with water. This invention can prevent overpickling and hydrogen embrittlement effectively, reduces gas pressure on pipe, improves working condition greatly, and has wide application for device protection.
Owner:自贡市轻工业设计研究有限责任公司

Process for separating americium from other metallic elements present in an acidic aqueous or organic phase

A process which allows separation of americium present in an acid aqueous phase or in an organic phase from the other metal elements also found in this phase, by complexation of the americium with a water-soluble ethylenediamine derivative; and a process for selective recovery of americium from an acid aqueous phase containing, in addition to americium, other metal elements, which comprises the application of this separation process.
Owner:ORANO RECYCLAGE +1

Triblock polypropylene toughened and modified compatilizer as well as preparation method and application thereof

The invention discloses a triblock polypropylene toughened and modified compatilizer. The compatilizer is obtained by carrying out esterification reaction on the following raw materials in percentageby weight: 47.5-49.75% of carboxylic acid anhydride grafted polypropylene, 47.5-49.75% of carboxylic acid anhydride grafted and toughened elastomer and 0.5-5% of diamine derivative in a solvent, wherein the diamine derivative is an ethylenediamine or ethylenediamine derivative. The invention further discloses a preparation method and application of the riblock polypropylene toughened and modifiedcompatilizer. The toughened and modified compatilizer has the advantages that the compatibility between polypropylene resin and the corresponding elastomer is improved, and the performance of a polypropylene toughened elastomer material is improved.
Owner:CHNA ENERGY INVESTMENT CORP LTD +1

Plating bath composition for electroless plating of gold and a method for depositing a gold layer

An electroless aqueous gold plating bath, comprising at least one source of gold ions and at least one reducing agent for gold ions, characterized in that it comprises at least one ethylenediamine derivative as plating enhancer compound according to formula (I), wherein the residues R1 and R2 comprise 2 to 12 carbon atoms and are selected from the group consisting of branched alkyl, unbranched alkyl, cycloalkyl or combinations thereof wherein the individual residues R1 and R2 are the same or different and a method of depositing of gold. The electroless aqueous gold plating bath is suitable toprovide soft gold layers useful for wire bonding and soldering applications which are required for electronic components.
Owner:ATOTECH DEUT GMBH

Long-acting glass antifogging agent

The invention discloses a long-acting glass antifogging agent, and belongs to the technical field of chemical reagents. The long-acting glass antifogging agent is prepared from the following raw materials in parts by weight: 1-5 parts of a modified acrylic polymer, 2-5 parts of an ethylenediamine derivative, 2-10 parts of propylene glycol ether, 1-3 parts of trimethoxyoctylsilane, 2-3 parts of lauramidopropyl betaine, 15-20 parts of isopropanol, 3-5 parts of tetra-n-butyl titanate, 2-5 parts of alkoxypyrrolidone and 50-60 parts of water. The glass antifogging agent provided by the invention isconvenient to carry, can be directly used by wiping, and has a good anti-fogging effect, no trace is left on the surface of glass after use, the antistatic ability is good, the anti-fogging period islong, and meanwhile good cleaning performance is achieved.
Owner:QINGDAO RONGHE TIANZE CULTURE TECH CO LTD

Plating bath composition for electroless plating of gold and a method for depositing a gold layer

An electroless aqueous gold plating bath, comprising at least one source of gold ions and at least one reducing agent for gold ions, characterized in that it comprises at least one ethylenediamine derivative as plating enhancer compound according to formula (I)wherein the residues R1 and R2 comprise 2 to 12 carbon atoms and are selected from the group consisting of branched alkyl, unbranched alkyl, cycloalkyl or combinations thereof wherein the individual residues R1 and R2 are the same or different and a method of depositing of gold. The electroless aqueous gold plating bath is suitable to provide soft gold layers useful for wire bonding and soldering applications which are required for electronic components.
Owner:ATOTECH DEUT GMBH

Process for production of ethylenediamine derivatives having halogenated carbamate group and acyl group, and intermediates for production of the derivatives

Ethylenedamine derivatives having a halogenated carbamate group and an acyl group can be produced by performing the catalytic hydrogenation of an aminonitrile having a halogen-substituted carbamate group in the presence of an acid and then performing the acylation of the resulting product. The aminonitrile (i.e., a starting material) can be prepared in a high yield by performing the halogenated carbamatation of an amino acid amide in the presence of water and then reacting the resulting product with a deoxidizing agent such as a vilsmeier reagent.
Owner:MITSUI CHEM INC

Glycinamide derivative as well as preparation method and application thereof

The invention discloses a glycinamide derivative as well as a preparation method and application thereof. The derivative with a structural formula as shown in the following formula (I) is provided; and in the formula, R1 is selected from Cl and H, R2 is one selected from H, CH3 and CH2CH3; and X is one selected from NHCH3, NHCH2CH3, N (CH2CH3) 2, a pyrrolyl group and a piperidyl group. During preparation, different phenyl glutaric acid compounds are selected as raw materials and are respectively subjected to amidation reaction twice with an aminoindane hydrochloride derivative and an ethylenediamine derivative to obtain a target derivative. The prepared derivative or the pharmaceutically acceptable salt thereof, or the pharmaceutical composition thereof can be used as an S-adenosyl homocysteine hydrolase inhibitor for the development of antitumor drugs .
Owner:GUILIN MEDICAL UNIVERSITY

Fullerene single catechol derivative intermediate, preparation method thereof and purposes thereof

The invention discloses a fullerene single catechol derivative intermediate, a preparation method thereof and purposes thereof. The preparation method is characterized in that 0.3-14 parts of 3,4-dibenzyloxybenzoic acid are dissolved in 2-10 parts of tetrahydrofuran at -15--18 DEG C, 0.01-1 part of triethylamine is added in the solution, 0.09-1 part of ethyl chloroformate is dripped in the reactor, the solution is stirred for 2-3 hours, triethylamine hydrochloride is removed through filtering, THF is removed in a pressure reducing mode, 0.1-4.0 parts of fullerene ethylenediamine derivatives intermediates IV, and 16-100 parts of methylbenzene are added in the solution and react at 140-150 DEG C, TLC is used for detecting reaction progresses, the methylbenzene is removed after filtration and pressure reduction, 1-10 parts of dichloromethane are added and dissolved in the solution, 6-7 parts of saturated salt water is used for washing for three times, 10-12 parts of saturated sodium bicarbonate are sued for washing for five times, anhydrous sodium sulfate is used for washing organic phases, the column chromatography developing solvent includes dichloromethane and ethyl acetate with a ratio of 20:1, and 0.05-2.5 parts of fullerene single catechol derivatives intermediates V are obtained. The productive rate is 30.6%-38.8%.
Owner:INST OF NUCLEAR PHYSICS & CHEM CHINA ACADEMY OF

A kind of three-block polypropylene toughening modified compatibilizer and its preparation method and application

The invention discloses a three-block polypropylene toughening and modifying compatibilizer, which is obtained by esterifying raw materials comprising the following components in weight percentages in a solvent: carboxylic anhydride grafted polypropylene 47.5%-49.75% , 47.5%-49.75% of carboxylic anhydride grafted toughened elastomer, 0.5%-5% of diamine derivatives; wherein, the diamine derivatives are ethylenediamine or ethylenediamine derivatives; the invention also discloses The preparation method and application of the above-mentioned three-block polypropylene toughened and modified compatibilizer are disclosed. The toughened and modified compatibilizer of the invention improves the compatibility between the polypropylene resin and the corresponding elastomer, and improves the performance of the polypropylene toughened elastomer material.
Owner:CHNA ENERGY INVESTMENT CORP LTD +1

Ethylenediamine derivatives

The invention relates a compound represented by the formula (1):Q1-Q2-C(═O)—N(R1)-Q3-N(R2)-T1-Q4  (1)wherein R1 and R2 represent H or the like; Q1 represents an aromatic ring, heterocyclic ring or the like; Q2 represents a single bond, aromatic ring, heterocyclic ring or the like; Q3 represents a groupor the like, Q4 represents an aromatic ring, heterocyclic ring or the like; and T1 represents —CO— or —SO2—, and a medicine which comprises the compound and is useful for thrombosis and embolism.
Owner:DAIICHI PHARMA CO LTD

Fullerene single catechol derivative intermediate, preparation method thereof and purposes thereof

InactiveCN103497141AImprove and broaden performanceImprove and expand functionalityOrganic chemistryAntinoxious agentsSodium bicarbonateEthyl chloroformate
The invention discloses a fullerene single catechol derivative intermediate, a preparation method thereof and purposes thereof. The preparation method is characterized in that 0.3-14 parts of 3,4-dibenzyloxybenzoic acid are dissolved in 2-10 parts of tetrahydrofuran at -15--18 DEG C, 0.01-1 part of triethylamine is added in the solution, 0.09-1 part of ethyl chloroformate is dripped in the reactor, the solution is stirred for 2-3 hours, triethylamine hydrochloride is removed through filtering, THF is removed in a pressure reducing mode, 0.1-4.0 parts of fullerene ethylenediamine derivatives intermediates IV, and 16-100 parts of methylbenzene are added in the solution and react at 140-150 DEG C, TLC is used for detecting reaction progresses, the methylbenzene is removed after filtration and pressure reduction, 1-10 parts of dichloromethane are added and dissolved in the solution, 6-7 parts of saturated salt water is used for washing for three times, 10-12 parts of saturated sodium bicarbonate are sued for washing for five times, anhydrous sodium sulfate is used for washing organic phases, the column chromatography developing solvent includes dichloromethane and ethyl acetate with a ratio of 20:1, and 0.05-2.5 parts of fullerene single catechol derivatives intermediates V are obtained. The productive rate is 30.6%-38.8%.
Owner:INST OF NUCLEAR PHYSICS & CHEM CHINA ACADEMY OF

Calcium complex of phosphorus contg. ethylenediamine derivs.

The invention relates to the calcium complex of[[(4R)-4-[bis[(carboxy-.kappa.O)methyl]amino-.kappa.N]-6,9-bis[(carboxy-.kappa.O)methyl]-1-[(4,4-diphenylcyclohexyl)oxy]-1-hydroxy-2-oxa-6,9-diaza-1-phosphaundecan-11-ylic-acid-.kappa.N6,.kappa.N9,.kappa.011]1-oxidato(6-)]-, tetrahydrogen (MS-325) and its salts, pharmaceutical agents that contain these complexes for the production of agents for the reduction of effects that are caused by heavy metals as well as processes for their production.
Owner:SCHERING AG

Preparation method of N-substituted ethylene diamine derivative

The invention discloses a synthetic method of an N-substituted ethylene diamine derivative as structure fragments for various drugs. The method comprises the following steps: first performing Michael addition reaction on aromatic amine or fatty amine or heterocyclic amine and ethyl acrylate, then performing hydrazinolysis, and finally performing Curtius rearrangement reaction, thus preparing the target compound. The method has the advantages of low cost, moderate conditions, easy operation, high total yield and the like.
Owner:HEFEI UNIV OF TECH

Chiral bis[N,O] palladacycle and synthesizing method thereof

The invention discloses chiral bis[N,O] palladacycle and a synthesizing method thereof. The method includes: allowing an iodobenzene derivative and a (1R,2R)-1,2-diphenyl ethylenediamine derivative which serve as the reactants to have reaction in an organic solvent in the presence of Pd(II) complex and a silver compound to obtain the chiral bis[N,O] palladacycle. The method has the advantages thatmethod is an efficient method for synthesizing the large-steric-hindrance and structure-modifiable chiral bis[N,O] palladacycle; the method is high in product yield, good in selectivity, high in catalyst catalyzing efficiency, mild in reaction condition, simple to operate and significant to the synthesis of the large-steric-hindrance and structure-modifiable chiral bis[N,O] palladacycle, and thesubstrate needed by the method is easy to synthesize, cheap and easy to obtain.
Owner:SUZHOU UNIV

Preparation and Application of a Reactive Mercury Ion Fluorescent Probe

The invention discloses a reactive mercury ion fluorescent probe and a preparing method as well as application thereof. The method comprises the following steps: (1) 5-aminophenyl and 10, 15, 20- trisulfonate phenyl porphyrin (PNH2) is dissolved in distilled water to form solution of 7.5 mg / ml. The triphosgene is dissolved in dichloromethane to form solution of 5 MuL / mL. After the two is mixed at equal volume, react at room temperature for 3 to 5 hours and then purified, resulted to 5 -phenyl isothiocyanate base and 10, 15, 20 - trisulfate phenylporphyrin (PNCS); (2) 5 - phenyl isothiocyanate base and 10, 15, 20 - trisulfate phenylporphyrin (PNCS) and ethylenediamine derivatives are mixed in an equimolar ratio and dissolved in a mixed solvent of acetone and distilled water, to form a total concentration of 20 mg / mL solution. Finally, the solution reacts at room temperature for 6-10 hours, and after purification, the final product porphyrin-thiourea (PT) is obtained. The probe has good water solubility and shows high sensitivity and selectivity for mercury ions, and shows significant colors and fluorescence changes when detecting mercury ions. Combined with laser confocal scanning microtechnique, the probe can also be obtained the detecting imaging of the mercury ion within living cells.
Owner:ZHEJIANG UNIV CITY COLLEGE

Pickling inhibitor and preparation method thereof

The preparation method for inhibitor used in convey-halogen pipe comprises: dissolving and mixing the material with amine salt, thiocyanic acid, ethanediamine derivative, surfactant, carboxylic acid and water; before using, adding surfactant and carboxylic acid, stirring evenly, and adjusting proper concentration with water. This invention can prevent overpickling and hydrogen embrittlement effectively, reduces gas pressure on pipe, improves working condition greatly, and has wide application for device protection.
Owner:自贡市轻工业设计研究有限责任公司

A chiral bis[n,o] cyclopalladium complex and its synthesis method

The invention discloses chiral bis[N,O] palladacycle and a synthesizing method thereof. The method includes: allowing an iodobenzene derivative and a (1R,2R)-1,2-diphenyl ethylenediamine derivative which serve as the reactants to have reaction in an organic solvent in the presence of Pd(II) complex and a silver compound to obtain the chiral bis[N,O] palladacycle. The method has the advantages thatmethod is an efficient method for synthesizing the large-steric-hindrance and structure-modifiable chiral bis[N,O] palladacycle; the method is high in product yield, good in selectivity, high in catalyst catalyzing efficiency, mild in reaction condition, simple to operate and significant to the synthesis of the large-steric-hindrance and structure-modifiable chiral bis[N,O] palladacycle, and thesubstrate needed by the method is easy to synthesize, cheap and easy to obtain.
Owner:SUZHOU UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products