The invention relates to a special ASIC (Application Specific Integrated Circuit) chip system for spaceflight. The special ASIC chip system comprises a MIPS (Million Instructions Per Second) nucleus, a PCI (Programmable Communications Interface) bus interface, an ISA (Internet Security And Acceleration) bus interface, a 1553B bus terminal interface, a 1553B protocol processor, a network interface, a CAN (Controller Area Network) interface, an EMI (External Memory Interface), AD acquisition control logic, OC door control logic, UART (Universal Asynchronous Receiver/Transmitter) serial port, PWM (Pulse Width Modulation) interface, a pulse counter PPC, PCM (Pulse Code Modulation) telemetry remote control module and a general input/output module, wherein the MIPS nucleus, the PCI bus interface, the ISA bus interface, the 1553B bus terminal interface, the 1553B protocol processor, a network interface, the CAN interface and the EMI are connected to an AMBA AXI (Advanced Microcontroller Bus Architecture Advanced eXtensible Interface) bus; and the AD acquisition control logic, the OC door control logic, the UART serial port, the PWM interface, the pulse counter PPC, the PCM telemetry remote control module and the general input/output module are connected to an AMBA APB (All Points Bulletin) bus; and the AMBA AXI bus is connected with the AMBA APB bus through an AXI/APB bridge.