The invention discloses a spatial light-to-fiber coupling system. The system comprises a pyramid prism, an inclined reflector, a light splitter, a first lens, a three-dimensional translation table, a1*2 optical fiber beam splitter, a calibration laser device, a receiving terminal, a photoelectric detector, a second lens, a first driver, a control processor and a second driver. The principle thatthe pyramid prism can return incident light in the original direction is used, and the zero point of the fiber axis is calibrated through the calibration laser device and the pyramid prism. After thespace light to be coupled enters the photoelectric detector and a fiber branch, the control processor acquires light spot data of the photoelectric detector and controls the inclined reflector to moveby taking the zero point of the fiber axis as a benchmark, and the optical axis deviation between the spatial light and a fiber is corrected so that the spatial light can be coupled into the fiber. The system is used for correcting light beam jitter and the optical axis deviation caused by atmospheric disturbance, environment vibration, temperature and gravity changes and the like, the coupling efficiency of the spatial light and the fiber is improved, and the system has an important application prospects in the field of spatial laser communication.