In certain example embodiments of this invention, improved seal systems that include flexible seals that are integrally formed (e.g., co-extruded) with other vehicle components, and/or methods of making the same, are provided. In certain example embodiments, some or all sealing system components may be integrated into trim and/or other components of the vehicle such as, for example, more structural elements of the vehicle that generally are required to be present. For instance, in certain example embodiments, the current U-shaped seal that typically is used to receive the glass of a window may be replaced with seal members attached to elements of the overall vehicle construct. Certain example embodiments accomplish this integration, for example, by forming seal members together with the trim components, e.g., as a part of the roll form and/or extruding processes.