The invention discloses a production device of a PVA multi-product polymerization system, belonging to the field of chemical engineering. The system device comprises the following main equipment: a polymerizing pot 1, a polymerizing pot 1 resin pump, a polymerizing pot 2, a polymerizing pot 2 resin pump, a polymerizing column 1, a polymerizing column 1 pot pump, a PVAC storage tank, a polymerizing preheater, a mixer, a polymerizing pot 1 agitator, a polymerizing pot 1 jacket, a polymerizing pot 2 jacket, a polymerizing pot 2 agitator, a nitrogen gas buffer tank, a water seal pressurizing tank, a column 1 level control valve, dissolution methanol, a pot 2 outlet liquid mixer, a column 1 pot outlet resin mixer and a polymerizing column 2. The equipment is interconnected through pipelines. The technical scheme of the invention can realize integrated control of a multi-product production process as well as safe and quick control of a product transformation process. The product transformation process needs not reduction in amount and can maintain the maximum amount as design. Meanwhile, an SIS system can satisfy treatment under special working conditions and ensure safety of a polymerization process.