The invention relates to hot-working die steel and an efficient preparation method thereof. The hot-working die steel comprises, by weight, 0.34%-0.45% of C, 1.00%-1.40% of Si, 0.50%-0.60% of Mn, lessthan or equal to 0.015% of P, less than or equal to 0.015% of S, 5.00%-6.00% of Cr, 1.00%-1.20% of Mo, 0.08%-0.12% of Nb, 1.00%-1.30% of Ni, and the balance Fe and inevitable impurities. The preparation method has the advantages that the alloy components are optimized, and mechanical diffusion and thermal diffusion are adopted to jointly act, so that the components of the hot-working die steel are homogenized, the time required for homogenization of the alloy elements is shortened, the production efficiency is improved, the production cost is reduced, the produced hot-working die has the Rockwell hardness of 55-57 HRC, the isotropic performance is good, and the thermal stability is good.