The invention relates to an efficient mute vehicle-mounted air purifier. The efficient mute vehicle-mounted air purifier comprises a housing assembly, a filter element, a fan and a circuit assembly, wherein the filter element, the fan and the circuit assembly are arranged in the housing assembly, the fan is electrically connected with the circuit assembly, a purifying cavity and an air supplying cavity which are communicated are formed in the housing assembly, air inlets are formed in the periphery of the housing assembly in a 360-degree mode and correspond to the purifying cavity, an air outlet is formed in the top of the air supplying cavity, the air supplying cavity is located on the purifying cavity, the filter element is in a tubular shape and arranged in the purifying cavity, the air inlet is communicated with the air supplying cavity through the outer wall of the filter element, and the fan is arranged between the bottom of the air outlet and the upper portion of a center hole of the filter element. The air inlets of the vehicle-mounted air purifier are annularly formed in the outer side of a purifier body, air inlet without dead angle in a 360-degree mode is achieved, air inlet amount in unit time is increased, and the purifying efficiency is higher; the air outlet is formed in the top of the purifier body, air has enough travel in the purifier body and is fully purified, and air purifying quality is improved; in addition, the structure can effectively reduce noise.