The invention discloses a full-automatic single wet tissue packaging machine, which comprises a rack and optical fiber probes mounted on the rack, wherein a rotary shaft for fixing a raw material, a feeder for feeding the row material, a lifting air cylinder for controlling the feeder to move up and down, a correcting mechanism for correcting the row material, a longitudinal folding mechanism, a horizontal folding mechanism, a cutting mechanism, a wrapping mechanism, a rotary shaft for fixing a packaging film, a coding machine for printing the packaging film, a packaging film pulling mechanism for conveying the packaging film, a longitudinal packaging film sealing mechanism, a packaging film pulling exhaust mechanism, a horizontal packaging film sealing mechanism, a blowing removing nozzle, a finished product conveyer belt, a counting and stacking mechanism and an electric control box for controlling the operation of each mechanism are arranged on the rack. The full-automatic single wet tissue packaging machine solves the problem of raw material waste caused by the incorrect folding width of the material, can automatically inspect products, increases the packaging quality of the products, has an automatic counting and stacking function, and solves the problem that manual counting is difficult.