The invention discloses rheumatism oral liquid and a preparation method of the rheumatism oral liquid. The rheumatism oral liquid is prepared by the following steps: carrying out secondary alcohol extraction and concentration on cayenne pepper, radix angelicae pubescentis, a black bee honeycomb, black ants, root and herb of saussurea acroptila, safflowers and radix euphorbiae ebracteolatae, after the secondary alcohol extraction and concentration, adding cortex cinnamomi oil, and standing and filtering an obtained mixture to obtain the rheumatism oral liquid. The rheumatism oral liquid adopts a prescription prepared by pure natural traditional Chinese medicinal materials, has the efficacy of expelling wind, removing dampness, promoting blood circulation and activating meridian, is used for treating symptoms including soreness, numbness, swell, pains and inhibited bending and stretching of joints, limbs and the like caused by meridian invasion of exogenous evils, poor blood circulation and blood circulation obstruction, is simple in dosage form and convenient to take, can effectively treat various rheumatic diseases, is simple in preparation technology and low in equipment requirements, is environment-friendly and is suitable for industrial enlarged production.