The invention discloses meridian-activating to stop pain tincture and a preparation method of same. The medicine includes, by mass, 1-5 parts of angelica sinensis, 1-3 parts of flos carthami, 1-3 parts of red peony roots, 1-3 parts of dipsacus roots, 1-3 parts of radix clematidis, 1-3 parts of rhizoma drynariae, 1-5 parts of lycopodium clavatum, 1-5 parts of Chinese starjasmine stem, 1-3 parts ofradix aconiti preparata, 1-5 parts of caulis spatholobi stem, 1-3 parts of radix cyathulae, 1-3 parts of pericarpium citri reticulatae viride, 1-3 parts of peach kernels, 1-3 parts of divaricate saposhnikovia roots, 1-3 parts of notopterygium roots, 1-3 parts of radix angelicae pubescentis, 1-3 parts of agilawood, 1-3 parts of scorpions, 1-3 parts of centipedes, 1-3 parts of long-noded pit vipers,1-3 parts of camphor, 1-3 parts of menthol, 1-3 parts of wintergreen oil, and 50-100 parts of 60-degree baijiu. The medicine solves the problems that swelling-eliminating and pain-relieving medicinesin the prior art are low in medicine liquid content and poor in curative effects.