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155 results about "Bone morphogenetic protein 2" patented technology

Bone morphogenetic protein 2 or BMP-2 belongs to the TGF-β superfamily of proteins.

Naphtholactams and lactones as bone morphogenetic protein active agents

InactiveUS6030967AHigh toxicological thresholdReduce riskBiocideOrganic chemistryActive agentCarbon chain
PCT No. PCT / JP97 / 02858 Sec. 371 Date Oct. 30, 1997 Sec. 102(e) Date Oct. 30, 1997 PCT Filed Aug. 19, 1997 PCT Pub. No. WO98 / 07705 PCT Pub. Date Feb. 26, 1998A compound of the formula: wherein Q is an optionally substituted carbon atom or N(O)p wherein p is 0 or 1; Y is an optionally substituted methylene group, S(O)q wherein q is an integer of 0 to 2, or an optionally substituted imino group; Z1 is a C1-3 alkylene group which may have an oxo group or a thioxo group and may contain etherified oxygen or sulfur within the carbon chain; Z2 is an optionally substituted C1-3 alkylene group; Ar is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group; one of R1 and R2 is a hydrogen atom, a halogen atom, a hydroxyl group, an optionally substituted lower alkyl group, or an optionally substituted lower alkoxy group; the other is a halogen atom, a hydroxyl group, an optionally substituted lower alkyl group, or an optionally substituted lower alkoxy group; or R1 and R2 taken together with adjacent -c=c- form a ring; and ring A is a benzene ring which may be substituted in addition to R1 and R2; or a salt thereof.
Owner:TAKEDA PHARMA CO LTD

Use of morphogenetic proteins to treat human disc disease

InactiveUS7435260B2Bone implantDiagnosticsDiseaseImmune depression
Bone morphogenetic proteins (BMPs) are introduced into an affected intervertebral disc without the inclusion of disc cells. The inventions applies to all known and yet-to-be developed or discovered BMPs, including BMP-1, -2, -3, -4, -5, -6, -7, -8, -9, -10, . . . BMPn. The BMP(s) may be obtained from natural and / or recombinant sources. The BMP(s) may be introduced using any surgical technique, including percutaneous or laparoscopic approaches. As one delivery mechanism, a passageway may be formed through the annulus, with the substances then being introduced through the passageway. Alternatively, a carrier may be sewn or otherwise adhered to the inside or outside of the existing annulus using standard surgical procedures. Additional therapeutic substances such as culture medium, growth factors, differentiation factors, hydrogels, polymers, antibiotics, anti-inflammatory medications, or immunosuppressive medications could be introduced in conjunction with the BMP(s).
Owner:ANOVA

Use of blocking agents of bone morphogenic protein (BMP) signalling for the treatment of neuroinflammatory and neurodegenerative diseases

The invention provides pharmaceutical compositions for the treatment of neuroinflammatory or neurodegenerative diseases comprising a single or a combination of several blocking agent(s) of Bone Morphogenic Protein (BMP) signaling. The invention further provides methods of treatment of neuroinflammatory or neurodegenerative diseases comprising administering to a patient in need thereof the pharmaceutical compositions of the invention.
Owner:THE MEDICAL RES INFRASTRUCTURE & HEALTH SERVICES FUND OF THE TEL AVIV MEDICAL CENT

Combined adeno-associated virus and adenovirus cocktail gene delivery system for high efficiency gene expression without eliciting immune response in immuno-competent subjects

The present invention provides an efficient gene delivery system using Adeno-Associated Viral (AAV) vector in gene therapy. Furthermore, the invention provides a combined AAV and Adenovirus (Adv) cocktail gene delivery system which is even more efficient in in vivo gene delivery and expression without eliciting any significant immune responses in an immunocompetent subject. In particular, the invention provides a therapeutic agent and methods for preventing, treating, managing, or ameliorating various diseases and disorders including, but not limited to, bone diseases, by delivering Bone Morphogenetic Protein 2 (BMP-2) for new bone formation via gene therapy using said system. The invention provides a nucleic acid molecule comprising an AVV vector and a promoter operably linked to a sequence encoding BMP-2; and a nucleic acid molecule comprising an Adv vector and a promoter operably linked to a sequence encoding BMP-2, as well as vectors and host cells comprising said nucleic acid molecules, respectively.
Owner:THE UNIVERSITY OF HONG KONG

Cell model obtained after targeted knockout of rabbit bone morphogenetic protein-2 (BMP2) gene based on CRISPR/Cas9 and application thereof

The invention relates to a cell model obtained after targeted knockout of a rabbit BMP2 gene based on CRISPR / Cas9 and application thereof, belonging to the technical field of molecular biology and biomedicine. According to the invention corresponding oligos are synthesized for three targeting sites of the rabbit BMP2 gene on the design principles of CRISPR / Cas9 and are constructed on px458 vectors; and a CRISPR / Cas9 system is constructed directed at the three targeting sites in rabbit mesenchymal stem cells, and the CRISPR / Cas9 system can effectively knock out the rabbit BMP2 gene, is easy to operate and has high rabbit BMP2 gene knockout efficiency. The cell model disclosed in the invention can greatly promote research related to the functions and signaling pathways of the BMP2 gene.
Owner:QINGDAO JIAOZHOU CENT HOSPITAL

Method for editing swine BMP15 (bone morphogenetic protein 15) gene by using CRISPR/Cas9

The invention discloses a method for editing a swine BMP15 (bone morphogenetic protein 15) gene by using CRISPR / Cas9. The method comprises the steps as follows: designing two gRNAs on an exon 1 of theBMP15 of a target swine genome, and constructing pX458 and pX459 vectors respectively, so that the BMP15 gene loses functions due to accurate deletion of DNA fragments. Compared with single gRNA medicated editing, the method has the advantage that the BMP15 gene can lose functions more effectively due to accurate deletion of DNA fragments of the exon.
Owner:SUN YAT SEN UNIV

Highly-mineralized osteogenic sponge compositions, and uses thereof

InactiveUS7563455B2Increased resorptionDiminish and eliminate capacityPeptide/protein ingredientsBone implantImplantation SiteProtein C
Osteogenic sponge compositions having enhanced osteoinductive properties for use in bone repair are described. The compositions include a quickly resorbable porous carrier, a more slowly resorbed mineral scaffold and an osteogenic factor, preferably a bone morphogenetic protein. The compositions enable increased osteoinductive activity while retaining a reliable scaffold for the formation of new bone at an implant site. Methods for therapeutic use of the compositions are also described.
Owner:WARSAW ORTHOPEDIC INC

Bone morphogenetic protein-2 in the treatment and diagnosis of cancer

The present invention pertains to the use of BMP-2, which is overexpressed in most common cancers, as 1) a target for cancer treatment therapies and 2) a means to diagnose cancer. The therapeutic component of this invention involves administering to a patient a composition that inhibits bone morphogenetic-2 activity. Such inhibition may be accomplished by ligands or antibodies that bind to BMP-2 or BMP-2 receptors. It may also be achieved by preventing the processing of pro-BMP-2, or blocking transcription or replication of BMP-2 DNA or translation of BMP-2 mRNA. The diagnostic component of the invention involves measuring the BMP-2 level in biological samples from both a patient and a subject and comparing those levels. Elevated levels of BMP-2 in the patient compared to the non-cancerous subject indicate cancer.
Owner:RUTGERS THE STATE UNIV

Bone Morphogenic Protein Binding Peptide

A cyclized peptide designated BMP Binding Peptide (BBP) is a synthetic peptide that avidly binds rhBMP-2. BBP increases the over-all osteogenic activity of rgBMP-2, increases the rate at which rhBMP-2 induces bone formation, and BBP induces calcification alone. Compositions and substrates including BBP, and methods of using BBP are useful in therapeutic, diagnostic and clinical applications requiring calcification and osteogenesis.
Owner:RGT UNIV OF CALIFORNIA +1

Controlled release of biopharmaceutical growth factors from hydroxyapatite coating on bioresorbable interference screws used in cruciate ligament reconstruction surgery

Controlled release of biopharmaceutical growth factors from a hydroxyapatite coating on a bioresorbable interference screw used in cruciate ligament reconstruction surgery on a human. Biologically active scaffolds, such as interference bone screws used for ligament fixation, made by growing calcium phosphate-based hydroxyapatite coatings on bioresorbable poly(α-hydroxy ester) scaffolds that provide controlled mineral dissolution and controlled release of bone morphogenetic protein-2. The biologically active scaffold provides improved bioavailability of BMP-2 growth factor that in turn provides enhanced graft-bone healing in the tibial bone tunnel. The coating method uses surface hydrolysis and modified simulated body fluid incubation which does not require solvent or heat and is conducted at room temperature.
Owner:WISCONSIN ALUMNI RES FOUND

Concentrated Protein Preparations of Bone Morphogenetic Proteins and Methods of Use Thereof

Disclosed herein are heretofore undescribed preparations of highly concentrated, solubilized proteins, such as but not limited to, Bone Morphogenetic Proteins. Such protein preparations can be formulated in an aqueous carrier at protein concentrations in excess of 10 mg / ml when using the methods of manufacture taught herein. Such methods yield stable protein preparations in either solubilized or lyophilized form. The protein preparations of the present invention are particularly beneficial when administered either locally or systemically, in part, because low administration volumes can be accomplished. This is especially important for local treatment of certain anatomic locations such as, for example, the synovial fluid of a joint when treating osteoarthritis with BMP-7 or the intradiscal space when treating degenerative disc disease with BMP-7.
Owner:MARIEL THERAPEUTICS

Detection method of nucleic acid

The present invention relates to an in vitro detection method that whether a sample contains target nucleic acid or not is detected by utilizing fusion protein of split-signaling morphogenetic protein and nucleic acid enzyme defect type Cas9 protein, a kit and a device.
Owner:INST OF MICROBIOLOGY - CHINESE ACAD OF SCI +1

Remedy

The present invention relates to a therapeutic agent or prophylactic agent for a disease requiring enhancement of bone morphogenetic protein production or promotion of osteogenesis; an agent for enhancement of bone morphogenetic protein production or an agent for promotion of osteogenesis, a food, beverage or feed for enhancement of bone mornhogenetic protein production or promotion of osteogenesis, characterized in that each comprises as an effective ingredient at least one compound selected from the group consisting of (a) an acidic saccharide, (b) a polyacrylic acid, (c) chlorogenic acid and (d) an oxidation processed product of chlorogenic acid, or an extract derived from algae.
Owner:TAKARA HOLDINGS

Preparation method of porous titanium-alloy femoral head support rod in bionic bone trabecula structure

The invention relates to a preparation method of a porous titanium-alloy femoral head support rod in a bionic bone trabecula structure. The support rod is prepared from titanium alloy powder by printing by adopting an SLM (selective laser melting) or EBM (electron beam melting) technology, wherein the titanium alloy powder serves as a raw material, has low modulus of elasticity and has a particle size of less than 45mu m. The structure of the support rod structure is similar to that of the human cancellous femoral neck bone trabecula so that the modulus of elasticity of the support rod is made to be similar to that of the human femoral neck as much as possible and the phenomenon that the support rod becomes loose can be reduced effectively. In addition, the surface of the support rod is provided with a poly(lactic-co-glycolic acid (PLGA) nanoparticle, bone morphogenetic protein-2 (BMP-2) and a vascular endothelial growth factor (VEGF) complex so that a growth factor slow-release effect can be achieved and the bone tissue can grow into the support rod.
Owner:维度(西安)生物医疗科技有限公司

BMP Mutants with Decreased Susceptibility to Noggin

The present invention provides modified, highly potent bone morphogenetic proteins. In particular, the present invention relates to the observation that BMP-6 and BMP-9 are less susceptible to inhibition by Noggin that are other members of the BMP subfamily of proteins. The present invention features chimeric bone morphogenetic proteins in which the middle portion of BMP-6 or BMP-9 replaces the middle portion of another BMP subfamily protein to cause resistance to inhibition by Noggin or other Noggin-like antagonists. Other embodiments of modified BMPs, compositions and methods of use are also included.
Owner:MARIEL THERAPEUTICS

Bone morphogenetic protein formulations

Protein formulations that can be lyophilized and are stable in organic solvents. The formulations contain bone morphogenetic proteins, lyoprotectants, and oxidation / reduction stabilizers. Optionally, the formulations may also contain solvent environment stabilizers. The protein formulations can be incorporated into a polymeric matrix to make medical devices for delivering the protein, and coatings for medical devices.
Owner:ETHICON INC

3D print scaffold material and preparation method and application thereof

The invention relates to a 3D print scaffold material and a preparation method and application thereof and particularly relates to a 3D print scaffold material for periodontal tissue reconstruction and a preparation method and thereof. The material comprises the following components: a stromal cell-derived factor-1 (stromal cell-derived factor-1, SDF-1) and a bone morphogenetic protein 2 (Bone Morphogenetic Proteins, BMPs). By adopting two functional molecules of SDF-1 and BMP2, endogenous stem cells are collected into a periodontal defect area, osteogenic differentiation is accelerated, periodontal tissue regeneration is accelerated, meanwhile, an individual bionic degradable polymer scaffold is designed on the basis of 3D printing, and the external form and the internal microstructure of the material is precisely controlled through a computer.
Owner:HOSPITAL OF STOMATOLOGY SUN YAT SEN UNIV

Remedies

The present invention relates to a therapeutic agent or prophylactic agent for a disease requiring promotion of osteogenesis or enhancement of bone morphogenetic protein production, an agent for promotion of osteogenesis or an agent for enhancement of bone morphogenetic protein production, and a food, beverage or feed for promotion of osteogenesis or enhancement of bone morphogenetic protein production, characterized in that each comprises as an effective ingredient a processed product derived from a plant. Also, the present invention relates to a method for measuring an enhancing action for bone morphogenetic protein production, a method for screening a substance having an enhancing action for bone morphogenetic protein production, and a method for preparing a substance having an enhancing action for bone morphogenetic protein production, each method using a specified cell.
Owner:TAKARA HOLDINGS

Human hard tissue repair material and preparation method thereof

InactiveCN102886075AOvercome the disadvantage of not being osteoinductiveStrong bone repair abilityProsthesisTissue repairHard tissue
The invention belongs to the field of a biomedical material, which is mainly applied to the preparation of a compound dosage form both of bone morphogenetic protein 2 active peptide and hydroxyapatite, wherein a sequence of the bone morphogenetic protein 2 active peptide is represented by SEQ ID NO: 1-10. A preparation method provided by the invention comprises the following steps: dissolving the bone morphogenetic protein 2 active peptide into normal saline or 5% of glucose solution, and then adding a hydroxyapatite support, combining the bone morphogenetic protein 2 active peptide on the surfaces of the hydroxyapatite particles to obtain the necessary compound dosage form both of the bone morphogenetic protein and hydroxyapatite after centrifugal separation, washing and drying, so as to obtain a human hard tissue repair material provided by the invention.
Owner:CENT SOUTH UNIV

Method for detecting PCR-RFLP of pig bone morphogenetic protein 15 gene polymorphism

A bone morphogenetic protein 15 (BMP 15) gene and the PCR-RFLP method for detecting its single nucleotide polymorphism (SNP) are disclosed. Its steps include extracting hog blood genom DNA, designing primer PCR amplifying, direct sequencing to amplified product, comparing and analyzing the sequence, and detecting SNP. It provides new marker for the marker aided breeding of pig.
Owner:HUAZHONG AGRI UNIV

Macromolecular conjugates of bone morphogenetic protein-7

A modified bone morphogenetic protein (BMP, also referred to as bone morphogenic protein) composition is described. The bone morphogenetic protein, in one embodiment, is BMP-7 which is chemically modified with a hydrophilic polymer, such as poly(ethylene glycol).
Owner:ALZA CORP

Anti-inflammatory agents and methods of their use

InactiveUS20060276385A1Reduce and prevent vascular inflammationPeptide/protein ingredientsAntipyreticCystine knotVascular inflammation
The present disclosure provides compositions and methods for reducing or inhibiting vascular inflammation, for example inflammation resulting from unstable blood flow conditions such as oscillatory shear. Representative compositions include an antagonist of BMPs, for example BMP4, or BMP receptors, for example BMPR-I and / or BMPR-II, in an amount sufficient to for inhibiting or reducing vascular inflammation by interfering with binding of bone morphogenic protein or a fragment thereof to bone morphogenic protein receptors. Exemplary BMP antagonists include polypeptides having an eight-, nine-, or ten-membered ring cystine knot structure. Representative BMP antagonists include, but are not limited to the CAN family of proteins, the chordin family that includes chordin and ventroptin, and noggin.
Owner:JO HANJOONG

Osteogenic induction medium and osteogenic differentiation method

InactiveCN106434539AEffective osteogenic differentiationExcellent osteogenic differentiationCulture processSkeletal/connective tissue cellsDexamethasoneVitamin C
The invention relates to the field of the biotechnology, in particular to an osteogenic induction medium and an osteogenic differentiation method. The osteogenic induction medium is prepared from vitamin C, dexamethasone, beta-sodium glycerol-phosphate, bone morphogenetic protein-2, a vascular endothelial growth factor and a basic medium. Multiple inducing factors in the osteogenic induction medium are combined to act on GMSCs (gingival mesenchymal cells) and have a synergistic effect, the osteogenic differentiation of MSCs can be effectively induced, and the osteogenic differentiation effect is remarkably superior to that of a conventional induction method.
Owner:GUANGZHOU SALIAI STEMCELL SCI & TECH CO LTD
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