178 results about "Micro orifice" patented technology

Implantable medical grafts fabricated of metallic or pseudometallic films of biocompatible materials having a plurality of microperforations passing through the film in a pattern that imparts fabric-like qualities to the graft or permits the geometric deformation of the graft. The implantable graft is preferably fabricated by vacuum deposition of metallic and / or pseudometallic materials into either single or multi-layered structures with the plurality of microperforations either being formed during deposition or after deposition by selective removal of sections of the deposited film. The implantable medical grafts are suitable for use as endoluminal or surgical grafts and may be used as vascular grafts, stent-grafts, skin grafts, shunts, bone grafts, surgical patches, non-vascular conduits, valvular leaflets, filters, occlusion membranes, artificial sphincters, tendons and ligaments.

An apparatus and method for generating a low concentration of gas within a carrier gas flow employing one or more miniature one-piece cylinders filled under pressure with a pure gas, or a concentrated gas balanced with an inert gas or gas mixture. Released from the cylinder through a pierced or other controlled opening, the flow of the gas is regulated by a pressure regulator and a micro orifice to be blended into a steady stream of diluent gas, typically ambient air, to form a desired gas concentration. No gas is generated if the pressure of the gas in the cylinder, which is monitored constantly by a pressure transducer, is below a predetermined level. The apparatus can be built into a portable device, or an automated docking station (or calibration station) for testing and calibrating gas detection and monitoring instruments, or into a fixed gas detection system for performing such functions.

A catheter for use in introducing fluid into a vessel or other bodily structure. The catheter comprises a stem and a restrictor. The stem has approximate a distal end thereof a porous section that defines microholes distributed thereabout, which are inclined by a predetermined angle in the proximal direction. Affixed to the stem, the restrictor includes a conically-shaped valve with an apex thereof defining an opening and pointing in the proximal direction. The opening generally decreases in size as the conically-shaped valve flattens out distally as the pressure of the fluid within the tip increases. The forces of the fluid flowing out of the opening of the restrictor and out of the microholes of the stem substantially balance thereby substantially eliminating both recoil and whipping of the catheter, thus enabling its position to remain exceptionally stable while the fluid is finely dispersed therefrom in a cloud-like form.

Prosthetic implants designed to be implanted in the cornea for modifying the cornea curvature and altering the corneal refractive power for correcting myopia, and myopia with astigmatism, such implants formed of a micro-porous hydrogel material.

The invention relates to devices, devices for arraying biomolecules, including cells, methods for arraying biomolecules, assays for monitoring cellular movement, and systems for monitoring cellular movement. The devices include a support; a first layer configured to be placed in fluid-tight contact with the support, the first layer having an upper surface and defining a pattern of micro-orifices, each micro-orifice of the pattern of micro-orifices having walls and defining a micro-region on the support when the first layer is placed in fluid-tight contact with the support such that the walls of said each micro-orifice and the micro-region on the support together define a micro-well; and a second layer configured to be placed in fluid-tight contact with the upper surface of the first layer, the second layer defining a pattern of macro-orifices, each macro-orifice of the pattern of macro-orifices having walls and defining a macro-region when the first layer is placed in fluid-tight contact with the support and the second layer is placed in fluid-tight contact with the first layer such that the walls of the macro-orifice and the macro-region together define a macro-well.

The invention relates to devices, devices for arraying biomolecules, including cells, methods for arraying biomolecules, assays for monitoring cellular movement, and systems for monitoring cellular movement. The devices include a support; a first layer configured to be placed in fluid-tight contact with the support, the first layer having an upper surface and defining a pattern of micro-orifices, each micro-orifice of the pattern of micro-orifices having walls and defining a micro-region on the support when the first layer is placed in fluid-tight contact with the support such that the walls of said each micro-orifice and the micro-region on the support together define a micro-well; and a second layer configured to be placed in fluid-tight contact with the upper surface of the first layer, the second layer defining a pattern of macro-orifices, each macro-orifice of the pattern of macro-orifices having walls and defining a macro-region when the first layer is placed in fluid-tight contact with the support and the second layer is placed in fluid-tight contact with the first layer such that the walls of the macro-orifice and the macro-region together define a macro-well.

Compositions including a surface or film comprising nanofibers, nanotubes or microwells comprising a bioactive agent for elution to the surrounding tissue upon placement of the composition in a subject are disclosed The compositions are useful in medical implants and methods of treating a patient in need of an implant, including orthopedic implants, dental implants, cardiovascular implants, neurological implants, neurovascular implants, gastrointestinal implants, muscular implants, and ocular implants.

A steam distributor that uses a porous metal plate to replace the conventional screen plate of a steam shower for distributing steam to a moving web such as the web of a paper making machine. Steam showers using a steam distributor with this porous metal plate can deliver extremely uniform steam to the surface of a paper web. Profiling steam showers constructed by using an array of the steam distributors are able to deliver the best profiling results for various paper products. The porous metal plate can be considered as an equivalent of a screen plate with thousands of micro-orifices arranged tightly in both the machine direction and the CD direction.

An apparatus and method for generating a low concentration of gas within a carrier gas flow employing one or more miniature one-piece cylinders filled under pressure with a pure gas, or a concentrated gas balanced with an inert gas or gas mixture. Released from the cylinder through a pierced or other controlled opening, the flow of the gas is regulated by a pressure regulator and a micro orifice to be blended into a steady stream of diluent gas, typically ambient air, to form a desired gas concentration. No gas is generated if the pressure of the gas in the cylinder, which is monitored constantly by a pressure transducer, is below a predetermined level. The apparatus can be built into a portable device, or an automated docking station (or calibration station) for testing and calibrating gas detection and monitoring instruments, or into a fixed gas detection system for performing such functions.

A steam distributor that uses a porous metal plate to replace the conventional screen plate of a steam shower for distributing steam to a moving web such as the web of a paper making machine. Steam showers using a steam distributor with this porous metal plate can deliver extremely uniform steam to the surface of a paper web. Profiling steam showers constructed by using an array of the steam distributors are able to deliver the best profiling results for various paper products. The porous metal plate can be considered as an equivalent of a screen plate with thousands of micro-orifices arranged tightly in both the machine direction and the CD direction.

A heat dissipation system includes a cooling device, a condenser, a vapor conveying duct and a cooling liquid conveying duct. The cooling device includes a housing, and an orifice plate dividing an inner space of the housing into a liquid supply chamber and an evaporation chamber proximate to the heat source, and formed with multiple micro orifices each having a diameter ranging from 5 to 1000 micrometers. The condenser includes a fluid inlet, a condensing chamber and a fluid outlet. The vapor conveying duct connects a vapor outlet of the housing and the fluid inlet of the condenser. The cooling liquid conveying duct connects a cooling liquid inlet of the housing and a fluid outlet of the condenser.

A bone restoration body with a composite porous structure and a preparation method of the bone restoration body. The bone restoration body comprises a porous metal bracket and an infill body with a porous structure, wherein the porous metal bracket is of a three-dimensional net structure, a plurality of pores are arranged in the inner part of the porous metal bracket, and the infill body with the porous structure is fully filled in all the pores. The preparation method combines the direct metal rapid prototyping technology and the freeze drying technology and comprises the steps of preparing the porous metal bracket by a structural design and the direct metal rapid prototyping technology, pouring uniformly-mixed polymer solution or polymer / biological ceramics mixing solution into the porous metal bracket, carrying out freezing treatment, and then forming the infill body with the porous structure through freeze drying so as to obtain the bone restoration body with the composite porous structure, wherein the infill body with the porous structure has micropore characteristics. The bone restoration body has good mechanics compatibility, can obtain good bone conduction performance and bone induction performance, improves bone integration efficiency and can be used for clinical treatment of segmental bone defect of a bearing part.

Apparatus for forward and reverse transfer of fluids through capillaries, consisting of at least one capillary, a pressure generating or housing means, which preferably includes a box, having first and second means for aligning the capillaries from one set of wells to a second set of wells, and applied pressure differential transfers small amounts of liquid uniformly and in parallel. A method of accurately controlling a desired volume of fluid flow is particularly useful for transferring liquids to and from a microtiter dish to a Capillary Array Electrophoresis Microplate having liquid wells spaced in a radially symmetric configuration, or for maximizing desired transfer of the like or improved novel enhanced patterned arrays.

In accordance with an illustrative embodiment of the invention, a system for obtaining a fluidic sample from a container is presented. The container defines a volume for holding the sample, the volume being closed by a seal. An outer tube has a proximal end and a distal end, the proximal end shaped to permit piercing the seal. An inner tube has an end region axially movable within the outer tube between a piercing position, wherein an end of the inner tube in the end region is retracted from the proximal end of the outer tube, and a transmission position, wherein the end of the inner tube extends axially beyond the proximal end of the outer tube. The outer tube and the inner tube form a tube assembly. At least one of the tube assembly and the container can be moved to cause the outer tube to pierce the seal and, after the seal is pierced, the inner tube can be used in the transmission position to permit fluid transfer with respect to the volume.

The invention relates to a device for purifying air. An air cleaning machine comprises a groove body, wherein an air inlet is connected with a pipeline; the pipeline extends to the bottom of the groove body; a pipe orifice of one end, which is positioned at the bottom of the groove body, of the pipeline is enclosed; a pipe wall is provided with micropores; an air inlet hole is provided with a guiding device for guiding air into the pipeline; an air bubble guide plate which is used for covering the bottom of the groove body and is provided with an air dissipation port is further arranged in the groove body; the micropores of the pipeline are positioned below the air bubble guide plate; the air dissipation port of the air bubble guide plate is formed in one side of an air outlet of the groove body; the air bubble guide plate is arranged obliquely; and the air dissipation port is formed in a highest position. According to the air cleaning machine, air is introduced into water and is partitioned into micro air bubbles, and the micro air bubbles are fully contacted with water, so that an air purifying effect is achieved; and only water is used for purifying air, so that the cost of a purifying medium is low, and replacement is convenient.

The invention discloses a method for preparing a composite porous scaffold. According to the method, silk fibroin, collagen and chitosan are compounded together to form the white spongy composite porous scaffold. The porous scaffold prepared by the method can be applied in the technical fields of filling and repair of tissues and wounds, tissue engineering, medicament release and the like. The porosity of the prepared composite porous scaffold reaches more than 98 percent, the size distribution is 50 to 400 microns, and micro pores are intercommunicated. The obtained composite porous scaffold can keep the original form after being soaked into water, has the function of sponge, and can recover the original form after extrusion.

The invention relates to devices, devices for arraying biomolecules, including cells, methods for arraying biomolecules, assays for monitoring cellular movement, and systems for monitoring cellular movement. The devices include a support; a first layer configured to be placed in fluid-tight contact with the support, the first layer having an upper surface and defining a pattern of micro-orifices, each micro-orifice of the pattern of micro-orifices having walls and defining a micro-region on the support when the first layer is placed in fluid-tight contact with the support such that the walls of said each micro-orifice and the micro-region on the support together define a micro-well; and a second layer configured to be placed in fluid-tight contact with the upper surface of the first layer, the second layer defining a pattern of macro-orifices, each macro-orifice of the pattern of macro-orifices having walls and defining a macro-region when the first layer is placed in fluid-tight contact with the support and the second layer is placed in fluid-tight contact with the first layer such that the walls of the macro-orifice and the macro-region together define a macro-well.

The invention relates to an internal extracting device for calculus cavities of urinary systems. The internal extracting device comprises a guide tube and a guide wire. A net basket is arranged at a far end of the guide wire, a calculus extracting pocket is fixed onto the net basket and is in the shape of an elongated pocket by means of pre-plasticizing, an opening is formed in a surface of a near end of the calculus extracting pocket, and tiny holes are further formed in the calculus extracting pocket. The internal extracting device for the calculus cavities of the urinary systems has the advantages that large quantities of broken calculi, blood clots and pus clots can be extracted by the internal extracting device at one step, the internal extracting device is free of constraints of the inner diameters of the lumens of the ureters or the inner diameters of operation channels, broken calculus missing in calculus extracting procedures can be prevented, and the broken calculi can be effectively prevented from being poured into the kidneys by water current; injury to the walls of the ureters due to the broken calculi can be prevented, and accordingly the internal extracting device is safe and reliable.

The invention relates to devices, devices for arraying biomolecules, including cells, methods for arraying biomolecules, assays for monitoring cellular movement, and systems for monitoring cellular movement. The devices include a support; a first layer configured to be placed in fluid-tight contact with the support, the first layer having an upper surface and defining a pattern of micro-orifices, each micro-orifice of the pattern of micro-orifices having walls and defining a micro-region on the support when the first layer is placed in fluid-tight contact with the support such that the walls of said each micro-orifice and the micro-region on the support together define a micro-well; and a second layer configured to be placed in fluid-tight contact with the upper surface of the first layer, the second layer defining a pattern of macro-orifices, each macro-orifice of the pattern of macro-orifices having walls and defining a macro-region when the first layer is placed in fluid-tight contact with the support and the second layer is placed in fluid-tight contact with the first layer such that the walls of the macro-orifice and the macro-region together define a macro-well.

The invention relates to devices, devices for arraying biomolecules, including cells, methods for arraying biomolecules, assays for monitoring cellular movement, and systems for monitoring cellular movement. The devices include a support; a first layer configured to be placed in fluid-tight contact with the support, the first layer having an upper surface and defining a pattern of micro-orifices, each micro-orifice of the pattern of micro-orifices having walls and defining a micro-region on the support when the first layer is placed in fluid-tight contact with the support such that the walls of said each micro-orifice and the micro-region on the support together define a micro-well; and a second layer configured to be placed in fluid-tight contact with the upper surface of the first layer, the second layer defining a pattern of macro-orifices, each macro-orifice of the pattern of macro-orifices having walls and defining a macro-region when the first layer is placed in fluid-tight contact with the support and the second layer is placed in fluid-tight contact with the first layer such that the walls of the macro-orifice and the macro-region together define a macro-well.

The present invention relates to a surface porous bioactive implant and a preparation method thereof, a microporous implant with the aperture diameter of 10-250 mum is prepared from pure titanium powder or titanium alloy powder by 3D printing technology; the microporous implant is degreased and cleaned; 5mol / L NaOH is used for alkali heat treatment at 80 DEG C, and after sintering, the furnace cooling is performed; the obtained implant is placed in the simulated body fluid for mineralization at the processing temperature of 37.5 DEG C for 1-10 days to form a hydroxyapatite coating with the thickness of 0.01 to 20 mum on the surface; finally the obtained implant is ultrasonically cleaned for 5min by purified water, after flushing, the cleaning and packaging are performed; the complicated preparation process problem is solved, the three dimensional printing technology is simple, and the aperture diameter is adjustable and precise.

The invention provides preparation and application of a porous scaffold for guiding oral soft and hard tissue integrated repair. The integrated stent is prepared by combining electrostatic spinning with 3D printing. The composition and aperture of the integrated stent are in gradient change, and the upper layer is a b-FGF-loaded heparin grafted polycaprolactone / gelatin microporous fiber membrane, plays a barrier role and is used for guiding soft tissue regeneration; and the lower layer is a polycaprolactone / gelatin / hydroxyapatite macroporous scaffold and is used for guiding hard tissue regeneration. The interface of the upper-layer fiber membrane and the interface of the lower-layer 3D stent are firmly combined, the 3D stent has a through porous structure, and the compressive strength of the 3D stent is 13.86 MPa and is similar to that of cancellous bones of a human body. Both the upper-layer fibrous membrane and the lower-layer scaffold have good cell compatibility, and the lower-layer scaffold can effectively promote osteogenic differentiation of the BMSCs. The porous scaffold capable of effectively guiding in-vivo soft and hard tissue integrated repair is prepared and can be applied to synchronous regeneration of periodontal tissue and alveolar bone defects.

An acoustic board having displaced and passably abutted multiple through-holes comprises an outer surface and an inner surface, in which the first through-holes formed from the outer surface toward the inner surface and the second through-holes formed from the inner surface toward the outer surface are displaced and passably abutted thereby conjunctively constituting acoustically absorptive micro-orifices. Herein at least some of the second through-holes have a cross-sectional area of greater than 1 mm2 and are displaced and passably abutted to at least some of the first through-holes, thereby collectively forming a plurality of acoustically absorptive micro-orifices having a cross-sectional area of smaller than 1 mm2, and, in comparison with the total area of the acoustic board, the opening rate for the sum of the cross-sectional areas of all such acoustically absorptive micro-orifices is less than 3%.

The invention relates to a micropore-induced shock wave balloon catheter and system. The system is composed of electric field generating equipment and the shock wave balloon catheter; the electric field generating equipment comprises a man-machine interaction module, a control module, a power module and a high-voltage pulse output module; the electric field generating equipment is electrically connected with the shock wave balloon catheter; the shock wave balloon catheter comprises a long and thin component extending in the axial direction, a working balloon body arranged at the far end of the long and thin component, a wire and a liquid injection pipe which are arranged in a cavity of the long and thin component, an electric field generating mechanism arranged in the working balloon body, and a micropore-induced shock wave generating device wrapping the electric field generating mechanism; the electric field generating mechanism is electrically connected with the high-voltage pulse output module through a wire; a micropore mechanism penetrating through the wall of the micropore-induced shock wave generating device is arranged on the micropore-induced shock wave generating device; and the micropore mechanism can prevent liquid from entering through the surface tension of the micropore mechanism, so that the micropore-induced shock wave generating device can isolate the electric field generating mechanism from liquid flowing into the working balloon body.

A catheter for use in introducing fluid into a vessel or other bodily structure. The catheter comprises a stem and a restrictor. The stem has approximate a distal end thereof a porous section that defines microholes distributed thereabout, which are inclined by a predetermined angle in the proximal direction. Affixed to the stem, the restrictor includes a conic ally-shaped valve with an apex thereof defining an opening and pointing in the proximal direction. The opening generally decreases in size as the conically-shaped valve flattens out distally as the pressure of the fluid within the tip increases. The forces of the fluid flowing out of the opening of the restrictor and out of the microholes of the stem substantially balance thereby substantially eliminating both recoil and whipping of the catheter, thus enabling its position to remain exceptionally stable while the fluid is finely dispersed therefrom in a cloud-like form.

The invention provides a preparing method of an antibacterial three-dimensional porous bone implantation material. The preparing method includes the steps of performing surface activating treatment onthe three-dimensional porous bone implantation material to obtain a preprocessed material; performing micro-arc oxidation treatment on the preprocessed material to obtain an in-situ growing film layer formed on the surface of the preprocessed material and provided with antibacterial ions, wherein electrolyte adopted for micro-arc oxidation treatment includes antibacterial ions and functional substances, and the antibacterial ions are any one of or more of zinc ions, copper ions and silver ions; and performing hydrothermal treatment on the in-situ growing film layer to obtain the antibacterialthree-dimensional porous bone implantation material. The antibacterial three-dimensional porous bone implantation material obtained through the preparing method has an antibacterial effect. The macroaperture and micro aperture of the antibacterial three-dimensional porous bone implantation material coexist, micro pores in a micro-arc oxidation film layer on a porous wall can provide anchoring points for bone ingrowth, meanwhile the specific surface area of the implantation material is effectively increased, and the implantation material has an antibacterial function and biological functionsof bone ingrowth and bone induction.

The invention discloses a novel hip joint prosthesis which is composed of an overhauled acetabular cup. The overhauled acetabular cup is composed of two parts, namely, the micropore structure part and the solid structure part, and the micropore structure part of the overhauled acetabular cup and the acetabular fossa of the human body are in direct contact; the overhauled acetabular cup is of a hemispheric structure, the micropore structure part is arranged on the hemispheric outer surface of the overhauled acetabular cup, the solid structure part is arranged on the inner surface of the overhauled acetabular cup, and three to twelve through holes are formed in the hemispheric structure. The novel hip joint prosthesis has the advantages that the novel hip joint prosthesis can keep the good bone ingrowth pore structure, the strength of a product can also be guaranteed, and cleaning is easy; the micropore structure with the thickness being 1.5 mm is designed on the work surface of the novel hip joint prosthesis, the rest is solid, the thickness of the pore structure is only 1.5 mm, and few challenges are brought to cleaning and disinfection; meanwhile, due to the fact that the thickness of the pore structure is greatly reduced, when screws are implanted, the probability of generating scraps is greatly reduced.

The invention belongs to the technical field of environment protection techniques and household appliances. According to a micro pore bubble type air purifier, a deflector and an elementary filter net are arranged at an air inlet; a micro channel fine pore sieve board and a water absorption permeable layer are arranged at an air flow channel; air flows in from the air inlet, blows the liquid membrane on the surface of the elementary filter net, the liquid surface in a drip tray and the water absorption permeable layer for storing absorbed liquid in sequence and carries a large amount of liquid to form a gas-liquid mixture; the mixture passes through the micro channel of the sieve board mainly in a micro air bubble form; a bubbling layer is formed above the sieve board; a large amount of bubbles continuously burst and update, so that extremely high gas-liquid contact area and mass transfer efficiency are realized. According to the micro pore bubble type air purifier, liquid drops, liquid membranes and bubbles are comprehensively used for gas-liquid contacting and process strengthening; not only are liquid or solid pollutants effectively removed, and also gas pollutants are absorbed; the air purifier has high purification efficiency, is compact in structure, convenient to use and small in gas phase resistance and needs no consumable replacement.