263 results about "Micro orifice" patented technology

The invention discloses a gas self-excitation modulation device, an enhanced pollution aeration treatment system and an application method of the enhanced pollution aeration treatment system, through the arrangement of the gas self-excitation modulation device, intermittent modulation airflow matched with an orifice bubble generation process is formed, the instantaneous pulse acting force for upward separation of bubbles is increased, the bubble generation time is shortened, and the aeration bubble size is reduced; and the mass transfer rate of the gas-liquid interface is further improved. According to the invention, the existing laid aerator does not need to be replaced, the aerator material does not need to be modified, and the method is widely applicable to microporous aerators in any form; a water phase does not need to be driven to flow, so that energy consumption is greatly reduced, and adverse disturbance to a target water body is avoided; compared with a gas dissolving method and a jet flow air entraining method, the technology only drives a gas phase to enter a liquid phase, energy is saved, and meanwhile full-amount treatment of target liquid can be achieved. In addition, through sectional arrangement of the oscillation cavity self-excitation unit and the outflow unit, batch application can be carried out.

The invention relates to the technical field of skull repair, and discloses a personalized 3D printing porous composite hydroxyapatite coating skull repair body which comprises a truss structure, a plurality of porous areas are distributed on the truss structure, bionic bone trabecula structures are integrally formed in the porous areas, the truss structure is composed of hollow pipes communicating with one another, and the hollow pipes communicate with one another. A plurality of small holes and micro holes which are communicated with the interior of the hollow pipe are formed in the hollow pipe, and a composite coating of a hydroxyapatite coating and titanium is sprayed on the porous area; the invention provides a personalized 3D printed skull restoration with a porous composite hydroxyapatite coating. The problem that the biocompatibility, the bone induction capability and the bone ingrowth effect of an existing skull restoration need to be improved is solved.

The degradable breast prosthesis shaping net bag with the heterogeneous hierarchical porous structure is composed of the large-aperture structure layer and the micro-aperture structure layer, the large-aperture structure layer and the micro-aperture structure layer are formed by combining degradable fibers in a staggered mode, the degradable breast prosthesis shaping net bag and the breast prosthesis are perfectly conformal, and the mechanical property and the tissue adhesion property needed by the net bag are provided; the two cooperate to realize the integration function of the prosthesis and the tissue, and an additional suture fixing device is not needed; the overall shape of the net bag is designed to be the hemispherical upper cover and the lower end cover edge, the process of adding the net bag and a prosthesis is simplified, the operation efficiency is improved, the net bag has excellent mechanical performance and shaping capacity, the micropore structure is beneficial to adhesion and immigration of cells, rejection reaction of a body is reduced, the incidence rate of capsular contracture is remarkably reduced, and the net bag is suitable for popularization and application. The invention has the characteristics of hierarchical porous structure design, mechanical shaping capability customization and capsule contracture prevention, and provides an innovative breast prosthesis shaping and biological performance improvement scheme for breast cancer patients.

A protective umbrella and intracavity umbrella ribs are coaxially arranged on a conveying guide wire of the far-end embolism protection device, a supporting bracket of the protective umbrella is of a hollow structure, two first openings are formed in the near end of the supporting bracket and are symmetrically arranged along the central axis of the supporting bracket, and a covering film is fixed to the far end of the supporting bracket and wraps a part of the far end of the supporting bracket; a plurality of holes are formed in the covering film, the intracavitary umbrella ribs are located in the supporting support and are of a hollow structure, and second openings of the intracavitary umbrella ribs face the far end of the supporting support. The intracavity umbrella ribs and the covering film form a double-layer filtering structure, so that the situation that thrombus clots are accumulated in the inner cavity of the protection umbrella is effectively improved, the probability that meshes / micropores of the protection umbrella are blocked is reduced, and sufficient blood supply of a nervous system is ensured; the intracavitary umbrella ribs and the supporting bracket are coaxially arranged, so that the stability of the protective umbrella in the blood vessel is improved, the protective umbrella is not prone to inclination, and effective capture of free thrombus is ensured; the arrangement of the two first openings ensures that an effective capture channel can be provided even in an inclined condition.

The invention discloses an injection molding device with an auxiliary mold micro-opening and glue sealing structure, and the device realizes accurate micro-opening of a movable mold plate through the synergistic effect of a mold opening and closing assembly and an auxiliary mold opening assembly, so that the micro-opening distance of the movable mold plate can be kept in a controllable range of 0.5 mm-2mm. Therefore, the uniformity of mold cavity exhaust and material flow distribution in the injection molding foaming process is effectively improved; in addition, the structure of the injection screw is optimized, and a spiral dispersing element area and a pin mixing area are sequentially arranged at the head of the injection screw, so that the gas-containing molten material can be efficiently dispersed and homogenized, and the micropore structure and the surface quality of the interior of a product are remarkably improved. Compared with the prior art, the consistency and the size precision of the product can be remarkably improved, the defective rate is reduced, and the mechanical property and the appearance quality of the foamed plastic product are improved.

The invention discloses a self-adaptive bionic cancellous bone defect prosthesis and a design method thereof, and belongs to the technical field of medical prostheses, the prosthesis is composed of biological interface gradient microporous structure parts and a main body bionic truss supporting structure part, the biological interface gradient microporous structure parts are arranged at the two ends of the main body bionic truss supporting structure part, and the main body bionic truss supporting structure part is arranged on the main body bionic truss supporting structure part. The method is mainly used for reconstructing bone defects, bionically designing a truss part of a main body with consistent arrangement direction and form of human body bone trabecula through an established linear relation between CT gray value and bone density-elasticity modulus, adaptively matching mechanical conduction of a bone structure, reducing stress shielding effect, and improving bone defect reconstruction efficiency. Meanwhile, various complex mechanical working condition requirements of the prosthesis are met, the prosthesis failure risk is reduced, and the service life of the prosthesis is prolonged.

The invention discloses a compressor blade with a venturi tube micro-channel cooling structure, which realizes uniform distribution of cooling air and forms a stable air film cooling layer on the surface of the blade by arranging arc-shaped fine channels and fine pores on the tip of the blade and combining the series design of adjacent channels, thereby obviously improving the cooling effect. The inner wall of the channel is of a sharkskin microcosmic placoid scale structure, friction resistance is reduced, the airflow turbulence characteristic is enhanced, and therefore the heat exchange performance is optimized. The grooves penetrating through the surface of the blade prolong the service life of the blade by changing the flowing path of the air flow and destroying the formation of a liquid film cooling layer, and enhance the cooling effect and the contact between the air flow and the surface of the blade through linkage with the small channels, thereby further improving the heat exchange performance. And the micropores of the damping boss not only provide a damping effect, but also can effectively release cooling air, so that the combination of cooling and structural stability is improved. While the cooling effect is optimized, the working efficiency of the blade is remarkably improved, and the service life of the blade is remarkably prolonged.

The utility model discloses a pelvic brittle fracture bionic hollow screw manufactured based on the 3D printing technology. The pelvic brittle fracture bionic hollow screw manufactured based on the 3D printing technology comprises a screw body, and the screw body comprises a screw tail, a supporting part and a screw head; a thread, a diversion trench and a microporous structure are arranged on the supporting part; the micropore structure comprises a plurality of point position sets spirally arranged on the supporting part, and the difference between every two adjacent point position sets is one fourth of the circumference. According to the pelvic brittle fracture bionic hollow screw manufactured based on the 3D printing technology, the screw body manufactured through the D printing technology is arranged, a micro-pore structure distributed in a topological configuration mode can be conveniently arranged on the screw body, bone cement can be conveniently spread around the screw body in a more dispersed mode through the micro-pore structure, and therefore the bone cement can be more evenly distributed on the periphery of the screw body. And the micropore structure is beneficial to bone tissue growth, so that the long-term stability of the screw is improved.

Composite materials including a macroporous structure having a Voronoi architecture and a microporous biomaterial integrated into the macroporous structure are provided. Methods of making the composite materials and methods of using the materials to treat a bone defect are also provided.

The utility model discloses a balloon catheter for releasing drugs in a human body cavity. The balloon catheter comprises a three-cavity catheter, a drug delivery balloon and an expansion balloon, wherein the drug delivery balloon and the expansion balloon are arranged on the three-cavity catheter; the dilatation balloon is located in the drug delivery balloon, a drug delivery space is formed between the outer surface of the dilatation balloon and the inner surface of the drug delivery balloon, nylon strips are arranged on the outer surface of the drug delivery balloon, and drug release micropores are formed in the positions, between the nylon strips, of the balloon wall of the drug delivery balloon. The trachea can be expanded, drug treatment can be performed on narrow positions, multiple instruments are not needed to be matched for use, discomfort of a patient caused by the fact that the multiple instruments enter the airway for multiple times is avoided, and the risk of scratching the trachea is reduced; the dosage can be accurately controlled, and excessive liquid medicine is prevented from entering the human body; the operation is simpler, non-invasive treatment of the natural cavity of the human body can be achieved, foreign matter does not need to be implanted, and the operation can be repeated.

The invention discloses a nonlinear path planning method for a melt electrostatic direct writing stent guided by micropore characteristics, and relates to the technical field of additive manufacturing. Comprising the following steps: according to design requirements, defining binary functions L (x, y) and W (x, y), and respectively controlling spatial distribution of pore length and width of micropores; an XY plane is divided into orthogonal reference line grids through two groups of equidistant reference lines parallel to an X axis and a Y axis, namely an X (y) line and a Y (x) line, and each reference line can determine an upright plane, namely an X (y) plane and a Y (x) plane; and then determining geometric intersection points of the L / 2 (x, y) and W / 2 (x, y) function curves and an X (y) plane and a Y (x) plane determined by the reference line as path intersection points by using zigzag broken lines, after all the intersection points are obtained, sequentially connecting the intersection points to obtain a designed nonlinear path, and carrying out feasibility verification on the generated nonlinear path. The method provides a parameterized solution for micro-structure bionic design of the MEW stent, and is suitable for stent manufacturing with complex tissue regeneration requirements.

The invention provides an airway stent, and relates to the technical field of airway stents. Ozone gas is contained in the storage bottle body, the internal space of the storage bottle body is in a circular ring shape, and a sealing bottle cap is buckled on the top of the storage bottle body; the memory metal support is located in the annular space in the storage bottle body. A rubber sealing ring is installed in the sealing bottle cap, the storage bottle body is sleeved with a movable sleeve shell, and the top of the movable sleeve shell is connected with the sealing bottle cap. A spring is connected into the movable sleeve shell and connected with the storage bottle body. When the memory metal stent is placed in the airway of a patient, the melt degradation film is degraded by body fluid, the inhibition medicine is slowly released from the slow release micropores, and granulation hyperplasia in the airway is inhibited for a long time. The problems that an existing medical airway stent mostly adopts a coating film drug-containing mode for adjuvant therapy, due to the fact that an outer side coating film is thin, the drug content is small, the drug contained in the coating film can be completely released in a short time, and the effect is not long enough are solved.

The invention provides a mold-testing-free shoulder joint prosthesis with a micropore tantalum coating and an installation method of the mold-testing-free shoulder joint prosthesis, and belongs to the technical field of medical instruments. Comprising a limiting type humerus prosthesis mechanism and a shoulder glenoid spherical prosthesis, the limiting type humerus prosthesis mechanism comprises a humerus handle body, a reference table is arranged at the top of the humerus handle body, a humerus adaptive disc is connected to the top of the reference table, a position correcting assembly is installed in the humerus adaptive disc, a sealing cover is connected to the top of the position correcting assembly, and the limiting type humerus prosthesis mechanism is connected with the shoulder glenoid spherical prosthesis. And a matching assembly is mounted on the top surface of the sealing cover. According to the humerus handle prosthesis, the humerus handle body, the inner handle body and the supporting handle are arranged to replace existing specification type humerus handle prostheses of multiple types, meanwhile, the orientation of a ball socket on the inner buckling disc is changed through the position correcting assembly so that the humerus handle prosthesis can adapt to shoulder glenoid spherical prostheses of different angles, and the problems that an existing humerus handle prosthesis is poor in universality, and the humerus burden of a patient is increased are solved.

The present invention relates to a guided bone regeneration device that is intended for the reconstruction of a buccal bone defect and is composed of an optionally micro-perforated smooth wall which is made of titanium and has a shape that covers said buccal bone defect.The present invention also relates to a process for manufacturing a device of the invention, comprising a step of constructing the device of the invention according to a three-dimensional representation obtained by means of a technique of maxillary-dental imaging of the bone defect.

The flow-adjustable perfusion balloon catheter comprises a catheter body, a balloon capable of being filled and a catheter base, a push rod channel and a filling channel are arranged in the catheter body, the filling channel is communicated with an inner cavity of the balloon, and a first connector and a second connector are arranged on the catheter base. Micropores are formed in the positions, located at the near end and the far end of the balloon, of the catheter body and are the near-end micropore and the far-end micropore respectively, the near-end micropore and the far-end micropore are communicated through a blood flow channel formed in the catheter body, and a blocking piece capable of blocking the near-end micropore or the far-end micropore is arranged in the blood flow channel. A push rod is arranged in the push rod channel, and the far end of the push rod is connected with the near end of the plugging piece. Compared with the prior art, by arranging the blood flow channel, effective circulation of blood flow can still be achieved after balloon plugging in the operation, complications caused by ischemia or hypertension in the operation are avoided, the perfusion blood flow can be adjusted in time according to different patient conditions, and the success rate of the operation is increased.

This invention relates to the field of factory environmental control technology, and discloses a distributed micro-orifice jet temperature control system and its control method for factory environments. The system includes a central unit, a main air supply duct, branch hoses, workstation-level electromagnetic regulating valves, female quick-connect fittings with leak-proof check valves, and terminal equipment with male quick-connect fittings. The terminal equipment is equipped with a hollow column composed of an outer and inner tube, a telescopic locking mechanism, and low-voltage cables with a helical spring-like extension structure. It also includes an AI controller, an ambient temperature sensor, a body surface temperature sensor, a personnel presence sensor, and a pulse width modulation generator. This invention uses leak-proof check valves to block airflow in vacant workstations to avoid energy loss, utilizes the helical spring-like extension structure to prevent breakage of low-voltage cables, and uses the AI ​​controller to adjust the flow cross-sectional area of ​​the workstation-level electromagnetic regulating valves based on multi-sensor parameters to achieve safe flow interruption and protect personnel at the workstations.

The invention relates to an instrument for transferring cerebrospinal fluid in a ventricle into a body cavity of other parts of a human body, and particularly discloses a cerebrospinal fluid drainage catheter component and a drainage system.The cerebrospinal fluid drainage catheter component comprises a catheter body, a plurality of rows of main long holes which extend in the circumferential direction and are distributed at intervals in the axial direction are formed in the wall of the catheter body, and a plurality of drainage holes are formed in the main long holes; a plurality of protruding parts are arranged on the two linear hole walls of the main long hole so that the main long hole can be divided into a plurality of micro holes. The pipe wall occupied by each row of main long holes is a first section, and the pipe wall between each two adjacent rows of main long holes is a second section; the driving component is used for driving one of every two adjacent second sections to axially move relative to the other second section, so that one end, in the circumferential direction, of the main long hole axially moves relative to the other end of the main long hole, and the two linear hole walls of the main long hole generate relative dislocation movement in the circumferential direction; therefore, the protruding part disturbs the interior of the main long hole.

The utility model relates to the technical field of soaking devices, and discloses a self-cleaning microporous membrane balloon catheter soaking device which comprises a box body, a sealing ring is arranged at the bottom of the box body, a rotating shaft is installed in the sealing ring, a baffle ring is fixedly connected to the outer portion of the lower end of the rotating shaft, and the lower end of the baffle ring is provided with a sealing ring. Limiting grooves are formed in the left side and the right side of the portion, located on the upper side of the baffle ring, of the rotating shaft, a lantern ring is arranged outside the upper end of the rotating shaft, limiting strips are fixedly connected to the left side and the right side of the inner wall of the lantern ring, and the outer walls of the limiting strips are connected to the inner sides of the limiting grooves in an up-down sliding mode. According to the balloon catheter soaking device, balloon catheters can be limited and fixed through the arranged fixing clamps, the multiple balloon catheters can be separated through the arranged containing disc, the situation that the balloon catheters are wound and damaged during soaking is avoided, soaking liquid in the box body can be pumped out through the gathering opening through the arranged conveying pump, and the soaking liquid is injected into the filtering box through the conveying pipe; and the soaking liquid is filtered through the filter plate, so that impurities in the soaking liquid are removed.

The utility model provides a pre-filling micropore injector, relates to the technical field of auxiliary structures of micropore injectors, and aims to solve the problems that when an existing micropore injector is actually used, a worker operates the injector to extract liquid medicine in an ampoule bottle and then injects the liquid medicine, the risk of bacterial contamination exists in the extraction process, and the injection time is prolonged. Comprising a pipe body, the left end of the pipe body is fixedly connected with a connector pipe, the outer wall of the pipe body is fixedly connected with a liquid injection pipe, the top of the liquid injection pipe is provided with an antibacterial plug block, the antibacterial plug block and the liquid injection pipe are matched in shape, a piston head is installed in the pipe body, and the right side of the piston head is fixedly connected with a push rod. A limiting sleeve is movably connected to the outer wall of the push rod, a handheld plate is fixedly connected to the right tail end of the push rod, and a connecting pipe is fixedly connected to the left end of the connector pipe.

The present application relates to a kind of nasal ala base subperiosteal implant retention method, belong to plastic surgery medical instrument technical field.The present application provides a kind of nasal ala base subperiosteal implant soft tissue suspension retention method and its implant and system.The method includes: implant is placed into maxillary bone subperiosteal interstice, and implant fixed wing is fixed with the soft tissue anchor point such as alar base ligament of alar elevating lip muscle using drug-loaded degradable suture and is suspended and fixed.Implant surface is provided with the microporous structure of guiding tissue ingrowth, and is provided with the drug depot recess of filling load immunomodulator temperature-sensitive hydrogel.Postoperative healing process, suture is released under the action of tension to accelerate proangiogenic factor and promote local vascularization, and temperature-sensitive hydrogel slow-release immunomodulator induces macrophage to repair type polarization, and cooperatively promotes the biological chimeric fixation of implant and soft tissue.The present application can realize the double stable retention of implant, reduces postoperative displacement risk.

The utility model discloses a disposable sterile ureter guiding sheath, and relates to the field of urinary intervention surgical instruments. The disposable sterile ureter guiding sheath comprises a sheath tube, a conical expansion tube and a sheath base, and the conical expansion tube and the sheath base are communicated with the two ends of the sheath tube respectively. According to the utility model, the polymer microporous membrane bag is arranged on the outer wall of the conical expansion tube, so that when a medical worker holds the sheath base by hand and penetrates the sheath tube into the urethra of a patient through the conical expansion tube, the polymer microporous membrane bag is extruded by the urethra; then, the human body lubricating liquid stored in the macromolecule microporous membrane bag seeps out through micropores of the macromolecule microporous membrane bag under the action of pressure, so that the human body lubricating liquid is smeared on the urethra wall and lubricates the urethra wall, and the situation that after the sheathing canal is inserted into the urethra, the sheathing canal rubs against the inner wall of the urethra, and consequently the inner mucosa on the inner wall of the urethra is damaged is avoided; the injury to a patient is caused, and the injury to mucous membranes in the operation process is effectively reduced.

Interbody fusion devices and related methods of manufacture are described herein. An example interbody fusion device can include a plurality of vertebral endplates, and a body extending between the vertebral endplates. The body and the vertebral endplates can define an internal cavity. Additionally, each of the vertebral endplates can include a lattice structure and a frame surrounding the lattice structure, where the lattice structure being configured to distribute load. Each of the vertebral endplates can also include a plurality of micro-apertures having an average size between about 2 to about 10 micrometers (μm), and a plurality of macro-apertures having an average size between about 300 to about 800 micrometers (μm).

This invention relates to the field of hydrogel electrode patch technology, and more particularly to a microstructured hydrogel patch and its preparation method, comprising a base layer, a conductive layer, and a hydrogel electrode layer stacked sequentially. The skin-contact surface of the hydrogel electrode layer is arrayed with micro-protrusions, each micro-protrusion having a micro-flared adsorption portion at its end, and an inward-curving portion at the end of the adsorption portion. A mesh-like breathing channel is provided between the micro-protrusions, and a breathable channel is axially opened on each micro-protrusion. A microporous one-way breathing valve communicating with the breathing and breathable channels is provided on the base layer. During preparation, the micro-protrusions and their end structures are formed using a mold, and the breathable channels are constructed. This invention enhances the adhesion between the patch and the skin through the micro-flared adsorption portion and the inward-curving portion, and combined with the breathable structure, improves breathability and wearing comfort, avoids skin allergies, and provides stable signal acquisition, making it suitable for long-term physiological signal monitoring.

This application discloses a single droplet generation device based on piezoelectric ceramics, including a microcavity liquid chamber, a piezoelectric driving component, a micro-orifice nozzle, a hydraulic adjustment system, and an electronically controlled driving module. The microcavity liquid chamber has a nozzle interface at its bottom, and its internal cavity volume is adapted to store a small amount of liquid and transmit pressure. The piezoelectric driving component includes a piezoelectric ceramic element, which is connected to the microcavity liquid chamber by bonding and is used to generate deformation under the drive of an electrical signal to apply pulse pressure to the liquid in the liquid chamber. The micro-orifice nozzle is detachably connected to the bottom of the liquid chamber, and its nozzle diameter is adjustable to control the initial size of the droplet. The electronically controlled driving module includes a power supply, a driving circuit, and a controller, which outputs an adjustable electrical signal to coordinately control the voltage amplitude, pulse width, and trigger frequency of the piezoelectric driving component, and is linked with the hydraulic adjustment system to achieve multi-parameter control of the droplet size. This application achieves high-precision droplet control through the coordination of the piezoelectric driving component and the electronically controlled module.

The invention discloses a trachea cannula with an aerosolization drug delivery function under an air bag. The trachea cannula comprises a main tube body, the air bag, an air bag inflation tube and an independent drug delivery channel embedded in the tube wall of the main tube body. The far end of the channel extends below the attachment point of the air bag and is communicated with the air channel through a plurality of micropores, and the near end of the channel is provided with a standardized connecting port. Medicine can be accurately conveyed to a dead space area below the air bag, efficient phlegm reduction, blocking prevention and infection resistance are achieved, negative pressure suction is supported, administration-suction integrated operation is formed, and nursing safety and convenience are remarkably improved.

An intelligent controllable super-deformation nose prosthesis belongs to the field of plastic surgery medical instruments and is characterized in that a concave hollow omega-shaped structure frame main body shell layer, a Janus interface outer coating and an intelligent response material are combined to construct a'anatomy-structure-function 'integrated nose prosthesis, a micropore design and a hydroxyapatite coating are performed on the ventral side of the nose prosthesis, and the micro-pore design and the hydroxyapatite coating are performed on the ventral side of the nose prosthesis. A nose prosthesis structure with high fitness and high stability is formed, smooth design and spermidine coating are carried out on the back side of the nose prosthesis, so that envelope formation is inhibited, envelope constraint is avoided, and the super-directional deformation performance is achieved in combination with the design of the concave hollow omega-shaped structure. By applying the intelligent response material, non-invasive deformation adjustment can be carried out through temperature signals in an operation or after the operation, and the clinical requirements of fine adjustment in the operation and after the operation are met. The nasal prosthesis can be applied to the scenes of plastic surgery, postoperative modification, repair and reconstruction and the like, and the higher-level medical and aesthetic requirements are met.

A strap (3), two complementary fastening elements (4, 5) configured to close the collar (1) into a self-closing loop, a sheath (2) attached to the strap (3), said sheath (2) having an inner face with a micro-perforated body and an outer face made of waterproof material, the inner face having a pouch (11) with an opening (12) configured to allow the diffusion of an antiparasitic treatment molecule through said micro-perforated body. Figure for the abstract: Fig 1

The invention relates to the technical field of implant processing, in particular to a femtosecond laser for implant processing and a control method thereof.The method comprises the steps that the bone density of alveolar bone is obtained to determine the processing mode of the femtosecond laser; determining whether the processing process of a single stage is qualified or not based on the micropore distribution density of the implant surface in the corresponding processing mode; the vibration frequency of the implant in the rotating process is determined based on the judgment result that the machining process of the single stage is unqualified, so that the weight of the balancing weight is adjusted; obtaining the edge smoothness of the micropore based on the adjusted implant to determine whether the dispersion compensation of the femtosecond laser is qualified or not, and adjusting the spacing of the diffraction grating pair based on the judgment result that the dispersion compensation is unqualified; and determining the standard deviation of the thread pitch to determine the qualification of the moving trajectory of the femtosecond laser, and optimizing the preset frequency or optimizing the pitch adjustment mode for the unqualified moving trajectory. According to the embodiment of the invention, the bone combination rate of the implant is improved.

The application discloses a kind of biomimetic silk fibroin cartilage scaffolds for cranium defect repair, belong to biomedical engineering technical field.To solve the problem of single structure, low bone formation efficiency and mismatching of mechanical properties and degradation rate of existing cranium repair scaffold, the application provides a kind of scaffold, which includes in order from outside to inside: biomimetic periosteum layer, bone conduction and vascularization layer and cartilage induction layer.Biomimetic periosteum layer is dense nanofiber membrane structure, and plays the role of physical barrier and osteoinduction;Bone conduction and vascularization layer is gradient porous structure with gradually decreasing aperture from outside to inside, aiming to guide the ordered growth of blood vessels and cells, and promote rapid vascularization;Cartilage induction layer is sponge-like microporous structure, used for forming stable cartilage template and starting endochondral ossification.The application simulates the natural bone healing process through structural biomimicry and functional zoning, synergistically promotes vascularization and osteogenesis, and realizes efficient biological repair of cranium defect.