The invention relates to a composite material structure failure analysis method based on mesomechanics degradation model, and three dimensional basic material performances of the composite material are input parameters, and material performances of the composite material after damage are obtained by mesomechanics calculating method, and seven common failure modes are taken into consideration, which comprise: fiber stretch, fiber compression, matrix stretch, matrix compression, fiber-matrix shearing, layered stretch and layered compression, and finally the material degradation mode in composite material progressive damage analysis is obtained for carrying out failure analysis of the composite material structure; the invention not only can accurately predict structure failure, but also can predict failure mode and position of the structure. According to the composite material structure failure analysis method based on mesomechanics degradation model provided by the invention, the material degradation model is obtained by theory analysis, thereby connecting macroscopic failure and microscomic mechanism of composite material, and compared to the present material degradation model based on experience or test, time and test cost are substantially reduced.