The invention discloses a four-slider zoom compensation mechanism of a zoom lens and relates to a zoom compensation mechanism, which belongs to the technical field of photoelectric instruments. The technical problem to be solved is to provide the four-slider zoom compensation mechanism of the zoom lens. The technical scheme is that the four-slider zoom compensation mechanism of the zoom lens comprises the following parts: a cover plate, a left adjusting nut, a left bearing retainer ring, a first steel ball, a first slider, a cam, a zoom carriage, a zoom guide shaft, a lens cone, a second steel ball, a second slider, a third slider, a compensation lens set, a compensation carriage, a zoom lens set, a fourth slider, a compensation guide shaft and the like. When the cam rotates, the zoom guide shaft performs curvilinear motion along a cam groove to drive the zoom lens set to move axially along the first slider and the second slider; meanwhile, the compensation guide shaft performs the curvilinear motion along the cam groove to drive the compensation lens set to move axially along the second slider and the forth slider, so that the focus distance regulation of a large-aperture zoom lens is realized, and regulation precision is high.