The invention discloses an automatic calibration system for remote-measuring equipment, and belongs to the testing technology of the remote-measuring equipment. The automatic calibration system comprises a human-computer interaction interface, a calibration signal analog system, a matrix switch, the signal remote-measuring equipment, a data collection/reception unit, an instrument control unit, a data processing platform and a software control platform. The automatic calibration system estimates output signals through the data analyzing and processing method. The output signals and reference signals input by the calibration signal analog system are compared, fitting of a transmission curve is carried out, a system transfer function and transmission accuracy are calculated, and a data table is generated to record transmission data and a characteristic function of each channel. The automatic calibration system can test transmission factors of direct current signal channels and alternating current signal channels automatically according to the user requirements, and can be used for testing the transmission factors of the channels of the remote-measuring equipment of different types fast and accurately on the basis of a virtual instrument platform, obtain a transmission channel model of the equipment to be tested visually and clearly, and provide the basis for correction of the transmission channels of the remote-measuring equipment under different external environments.