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34 results about "Valine methyl ester" patented technology

L-Valine methyl ester hydrochloride 99% CAS Number 6306-52-1. Linear Formula (CH 3) 2 CHCH(NH 2)COOCH 3 · HCl . Molecular Weight 167.63 . Beilstein Registry Number 3594960 . EC Number 228-620-9. MDL number MFCD00012497. eCl@ss 32160406 . PubChem Substance ID 24888503. SDS FTNMR (PDF) Similar Products.

Method for synthesizing valsartan

The invention discloses a method for synthesizing valsartan. The method comprises the following steps of: performing coupling reaction of 4'-brooethyl-2-cyanobiphenyl and L-valine methyl ester or L-valine methyl ester hydrochloride to obtain an intermediate I, namely N-(2'-cyanobiphenyl-4-methylene)-L-valine methyl ester or hydrochloride thereof, performing acylation reaction of the intermediate I and valeroyl chloride to obtain an intermediate II, namely N-(2'-cyanobiphenyl-4-methylene)-N-n-valery-L-valine methyl ester, finally putting the intermediate II into a system of zinc chloride and sodium azide and performing azido reaction to obtain an intermediate III, namely valsartan methyl ester, and hydrolyzing the intermediate III under alkaline conditions to obtain a target product. In the method, the yield of the valsartan methyl ester which is taken as an example is over 75 percent; and compared with other prior arts with the total yield of 40 percent, the method has the advantages that raw materials consumed for each ton of product are greatly reduced.
Owner:HEFEI UNIV OF TECH

Sodium tetraphenylborate-based enantiomer potential sensor and application of enantiomer potential sensor in detection of valinemethyl ester

The invention discloses a sodium tetraphenylborate-based enantiomer potential sensor and an application of the enantiomer potential sensor in detection of valinemethyl ester. The sodium tetraphenylborate-based enantiomer potential sensor is characterized in that sodium tetraphenylborate, a plasticizer and PVC are dissolved in tetrahydrofuran to prepare a PVC membrane, a step of air drying is carried out, one sheet of the PVC membrane is sliced to paste on one end of a PVC pipe, a filling liquid is injected in the pipe, an Ag/AgCl internal reference electrode is inserted to obtain a PVC membrane electrode, and the membrane electrode forms the enantiomer potential sensor with a calomel electrode. The enantiomer potential sensor is used for detecting a leucinemethyl ester enantiomer. According to the invention, the linearity range is 10<-4>-10<-1> mol<-1>, the slope is -47mV dec<-1>, the LOD(limit of detection) is 3.311*10<-4> mol L<-1>, the electrode enables chiral detection on valinemethyl ester, and the antipodal selective coefficient 1g(img file='DDA0000439081610000011.TIF' wi='160' he='71' /) is -2.36. The sodium tetraphenylborate-based enantiomer potential sensor and the application of the enantiomer potential sensor in detection of valinemethyl ester have the advantages of rapidity, economy, environmental protection, simple equipment and convenient operation, and can be used for on-site determination.
Owner:YUNNAN NORMAL UNIV

Betulinic acid-amino acid derivative, and preparation method and application thereof

The invention discloses a betulinic acid-amino acid derivative represented by a formula (I) and a preparation method thereof. The preparation method comprises the following steps of carrying out acylation reaction on a compound represented by a formula (a), acetic anhydride and pyridine under the protection of nitrogen so as to obtain a compound represented by a formula (b), reacting the compound of the formula (b) with oxalyl chloride so as to obtain a compound represented by a formula (c), then, respectively reacting the compound of the formula (c) with glycino methyl ester, L-alanine methyl ester, L-valine methyl ester, L-isoleucine methyl ester and L-glutamic acid methyl ester so as to obtain a compound represented by a formula (d), and washing, drying and purifying after reacting the compound of the formula (d) with LiOH so as to obtain the betulinic acid-amino acid derivative represented by the formula (I). The preparation method is high in synthetic efficiency and simple and convenient in process. The invention further discloses application of the betulinic acid-amino acid derivative represented by the formula (I) in preparation of a drug for treating osteoporosis; and the betulinic acid-amino acid derivative can be used as an osteoclast precursor differentiation inhibitor and has the obviously increased osteoclast precursor differentiation activity inhibition effect.
Owner:EAST CHINA NORMAL UNIV

Process for the preparation of valsartan

The present invention relates to a process for the preparation of pure Valsartan (I) substantially free from impurities of formulae (Ia), (Ib), and (Ic), which comprises: (i) condensing 2-(4′-bromomethylphenyl)benzonitrile of formula (II) with L-valine methyl ester hydrochloride of formula (V) in the presence of a base in a solvent to produce N-[(2′-cyanobiphenyl-4-yl)methyl]-(L)-valine methyl ester of formula (VI); (ii) treating the compound VI of step (i) with acid followed by treating with base to produce pure compound VI substantially free from dimeric impurity of formula (Via); (iii) reacting the pure compound of formula (VI) with n-valeryl chloride in the presence of a base to produce pure N-valeryl-N-[(2′-cyanobiphenyl-4-yl)methyl]-(L)-valine methyl ester (VII) substantially free from alkene impurity of formula (Vila); (iv) reacting the compound of formula (VII) with trialkyltin chloride and a metal azide in a solvent at a reflux temperature to produce N-(1-oxopentyl)-N-[[2′-(2-tributyltinte-trazol-5-yl)-(1,1′-biphenyl)-4-yl]methyl]-(L)-valine methyl ester of formula (VHIb) free from thermal degradation impurity (Villa); (v) hydrolyzing the compound of formula (VHIb) in the presence of alkaline conditions to produce Valsartan (I).
Owner:AUROBINDO PHARMA LTD

Sodium bromide application experiment method

The invention belongs to the technical field of valsartan intermediate synthetic product treatment, and particularly relates to a sodium bromide application experimental method. The method comprises the following steps: adding raw materials into a reaction kettle according to the weight ratio of sartan biphenyl, AIBN (azodiisobutyronitrile), sodium bromide, concentrated sulfuric acid, dichloromethane, drinking water and hydrogen peroxide, heating the reaction kettle, and dropwise adding hydrogen peroxide; after hydrogen peroxide is added, carrying out the heat preservation; when liquid becomes colorless and transparent, stopping heating, and carrying out the heat preservation; carrying out cooling, standing and layering; after liquid layering, taking out an organic layer and washing the organic layer; performing concentration after water washing, adding ethyl acetate into concentrated liquid, carrying out the crystallization, obtaining bromo-sartan biphenyl (4'-bromomethyl-2-cyanobiphenyl), and achieving the recycling of the bromine element, wherein the bromo-sartan biphenyl (4'-bromomethyl-2-cyanobiphenyl) obtained after recycling can be continuously used for valsartan intermediate N-[(2'-cyanobiphenyl-4-yl) methyl]-L-valine methyl ester hydrochloride, and therefore internal circulation of bromine is achieved, the cost is reduced, and environment-friendly emission is reduced.
Owner:安徽云帆药业有限公司

Potassium tetrakis(4-tert-butylphenyl)borate-based enantiopotential sensor and its application in the detection of valine methyl ester

The invention discloses an enantiomer potential sensor based on potassium tetrakis(4-t-butylphenyl)borate and application of the enantiomer potential sensor to methyl valinate detection. The enantiomer potential sensor is made by taking potassium tetrakis(4-t-butylphenyl)borate, a plasticizer and PVC, dissolving in tetrahydrofuran so as to prepare a PVC membrane, drying in air, cutting and getting a sheet and adhering to one end of a PVC pipe perfused with an internal perfusion fluid, inserting Ag / AgCl internal reference electrode to obtain a PVC membrane electrode, and combining with a calomel electrode for forming the enantiomer potential sensor. The enantiomer potential sensor is applied to detect enantiomers of methyl valinate. The linearity range is 10<-4>-10<-1> mol*L<-1>, the gradient is -39.5 mVdec<-1>, the detection limit is 3.548*10<-4> mold*L<-1>, the electrodes can help to perform chiral detection on methyl valinate, and the enantioselectivity coefficient is -2.20, wherein the calculation expression of the enantioselectivity coefficient is shown in the specification. The enantiomer potential sensor provided by the invention has the advantages of being rapid, economic, environment-friendly, simple in equipment, convenient to operate and applicable to on-site detection.
Owner:YUNNAN NORMAL UNIV
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