The invention discloses a hydrogen permeation measurement system. The system includes a vacuum pipeline unit, a heating temperature control furnace unit, and a mass spectrometer unit. The heating temperature control furnace unit is used for realizing the heating and temperature control effects on a test material, and the heating temperature control furnace unit is internally provided with a tooling test part of the test material; the test material is fixed at the tooling test part to realize testing of hydrogen permeability; the vacuum pipeline unit consists of a sample container, a first scroll vacuum pump, a first molecular pump and a hydrogen standard leak, the sample container and the hydrogen standard leak are connected to a trunk pipeline, one end of the trunk pipeline is connected to a vacuum pipe system arranged inside the heating temperature control furnace unit; the sample container is provided with a vacuum gauge; and the mass spectrometer unit includes a second scroll vacuum pump, a second molecular pump and an RGA molecular mass spectrometer that are connected in order, and the RGA mass spectrometer is connected to the trunk pipeline. The hydrogen permeation measurement equipment provided by the invention adopts an integral structure, the structure has good sealing performance, and the test structure is more accurate and reliable.