The invention provides a post-tensioned pre-stressed concrete beam pipeline grouting agent. The post-tensioned pre-stressed concrete beam pipeline grouting agent comprises the following components in parts by weight: 0.5-10 parts of a water reducing agent, 0.1-5 parts of a plastic expanding agent, 5-20 parts of a hardening swelling agent, 5-15 parts of a suspending agent, 0.001-0.05 part of a water-retaining agent, 0.01-0.5 part of an antifoaming agent, 0.1-4 parts of a thixotropic agent, 0.1-8 parts of a lubricating agent and 10-80 parts of a mineral admixture. The post-tensioned pre-stressed concrete beam pipeline grouting agent has the beneficial effects that the pipeline grouting agent has the characteristics of being quick in flow second, good in fluidity retaining, good in slurry stability, un-bleeding and the like, and therefore, the pipeline grouting agent can be used for effectively protecting steel strands, is suitable for post-tensioned pre-stressed concrete beams of road bridges and culverts, and also can be used for concrete structure pipeline grouting of general engineering.