The invention relates to a soil/underground water integrated injection system and a single-source, double-source and mixed micro-nano bubble liquid injection method thereof. A medicament configurationunit, an air supply unit and a water supply unit, which are controllably connected through different channels, are arranged in a container body and controllably connected to an injection buffer and an injection distributor, and a controller is used for controlling opening and closing of all the channels under different requirements to complete injection operation of water/medicament/air, micro-nano bubble water and mixed micro-nano bubble liquid. The system is mainly used for repairing polluted sites and underground water, can be applied to polluted sites of various geologies, has a strong medicament mixing performance, can perform various remediation operations on the polluted regions such as liquid injection, liquid-gas injection, aeration, and the like, can dredge an injection well, issuitable for polluted sites of various geologies , has the advantages of mobility, efficiency, long service life, high safety in construction process, good construction and operation environment, andthus has a good application prospect.