The invention discloses a BIM-based machine room arrangement and construction guidance method, relates to the technical field of building construction, aims to solve the technical problem that inan existing machine room design mode, the installation and connection conditions of various devices can be known only after construction is completed, real-time model guidance does not exist, so that repeated construction is easily caused, and material waste is cause;. According to the technical scheme, the method is characterized by comprising the following steps that S100, surveying and mapping are conducted on site, and a surveying and mapping database is established according to data obtained through surveying and mapping; s200, BIM modeling is performed according to the data obtained by surveying and mapping, and the position of the equipment is planned in advance in the modeling process; s300, path planning is conducted on the line pipes, the water pipes and the air pipes used in the machine room, and adjustment is conducted in real time according to planning; s400, according to the basis provided by the model, modular production is conducted on the line pipes, the water pipes and theair pipes of the machine room; and S500, modular assembling and splicing are conducted on the site of the machine room. The effects of reducing material waste in the construction process and effectively saving resources are achieved.