The invention provides a high-speed electric spindle gas sealing structure for a numerical control lathe, which comprises a spindle box body, wherein a bearing base is arranged in the spindle box body, a spindle is supported in the bearing base through a bearing, a front shaft shoulder end face of the spindle is separated from an inner ring of the bearing through a spindle spacer sleeve, a front flange is sleeved outside the spindle spacer sleeve, a sealing ring is sleeved outside the front shaft shoulder of the spindle, the front end of the spindle is connected with a hydraulic chuck, a waterproof cover is arranged between the hydraulic chuck and the spindle box body, a first-stage pneumatic rotary sealing structure is arranged between the inner circle at the front end of the waterproof cover and the outer circle of the hydraulic chuck, a second-stage pneumatic rotary sealing structure is arranged between the sealing ring and the front shaft shoulder of the spindle, a third-stage pneumatic rotary sealing structure is arranged between the front flange and the spindle spacer sleeve, a fourth-stage rotary sealing structure is arranged outside the front flange and the spindle spacer sleeve, the top of the spindle box body and bearing base, front flange and sealing ring are , provided with sealing gas circuit structure By adopting the four stage gas sealing, the internal air pressure of the spindle is large, the external air pressure is small, the cutting fluid and the scrap iron are effectively prevented from entering the electric main shaft, and the service life of the electric main shaft is prolonged.