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Implantation of cartilage

InactiveUS20090024224A1Promote recellularizationRestrict subsequent apoptosisBone implantSurgeryRepair cartilageViable cell
The invention is directed towards a process for implanting a cartilage graft into a cartilage defect and sealing the implanted cartilage graft with recipient tissue by creating a first bore down to the bone portion of the cartilage defect, creating a second shaped bore that is concentric to and on top of the first bore to match the shape and size of the cartilage graft, treating the first bore and the second shaped bore at the defect site with a bonding agent, treating the circumferential area of the cartilage graft with a bonding agent, inserting the cartilage graft into the defect site and wherein the superficial surface of the cartilage graft is at the same height as the surrounding cartilage surface. The first and second bonding agents may be activated by applying a stimulation agent to induce sealing, integration, and restoration of the hydrodynamic environments of the recipient tissue. The invention is also directed towards a process for repairing a cartilage defect and implanting a cartilage graft into a human or animal by crafting a cartilage matrix into individual grafts, cleaning and disinfecting the cartilage graft, applying a pretreatment solution to the cartilage graft, removing cellular debris using an extracting solution to produce a devitalized cartilage graft, implanting the cartilage graft into the cartilage defect with or without an insertion device, and sealing the implanted cartilage graft with recipient tissue. The devitalized cartilage graft is optionally recellularized in vitro, in vivo, or in situ with viable cells to render the tissue vital before or after the implantation. The devitalized cartilage graft is also optionally stored between the removing cellular debris and the recellularizing steps. The invention is further directed toward a repaired cartilage defect.
Owner:LIFENET HEALTH

Detunable Rf Tags

An RF tag suitable for use for electronic article surveillance comprises a tuned circuit formed by an inductive coil, which behaves as an antenna on a first side of a substrate electrically connected to a capacitor having plates on each side of an dielectric layer which may be the substrate. The capacitor and coil together form a resonant circuit. To permit deactivation of the tag the circuit also includes a discontinuity closed by a switch composition whose conducting properties can be changed from an insulating state to a conducting state when the tag is subjected to a strong electric field at or around its resonant frequency. The switch composition may, for example, be arranged to short out the capacitor plates or introduce additional capacitor plates or change the properties of the inductive coil. Alternatively the switch composition may introduce additional components (e.g. an IC) into the circuit. The tag may be arranged for sequential retuning to give a multifrequency tag. The switch composition may, for example, be an ink formulation containing 5 to 75% by weight a metal, preferably in the form of flakes. The switch composition may further contain oxygen scavengers or ionic species to improve the response of the switch composition and/or prevent the switch composition reverting to the insulating state.
Owner:QINETIQ LTD
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