16 results about "Bio optical" patented technology

The invention belongs to the technical field of satellite remote sensing application, and discloses an active and passive satellite remote sensing fused ocean three-dimensional chlorophyll field reconstruction method and system. According to the method, satellite-borne laser radar data is subjected to correction, signal processing and biological optical model inversion, and a chlorophyll a concentration vertical section along an orbit is obtained; forming a training set by the passive satellite observation optical variable and the marine environment variable of which the profile is matched with the space-time, so as to train a long short-term memory (LSTM) neural network model; and utilizing the trained model to reconstruct a three-dimensional chlorophyll a concentration field of a target area according to passive observation and environment variables of the target area. By fusing the advantages of a satellite-borne laser radar ICESat-2 satellite and a passive optical remote sensing satellite, three-dimensional chlorophyll a concentration field detection based on active and passive fusion remote sensing is developed, the structure and function of a marine ecosystem can be deeply known, and three-dimensional dynamic observation of the ocean is realized.

The invention discloses a polymer photosensitizer, nanoparticles and a preparation method and application of the polymer photosensitizer and the nanoparticles, and belongs to the technical field of biological optical diagnosis and treatment. The polymer comprises SPI and FPI, and SPI nano particles and FPI nano particles are prepared from the polymer. Under the irradiation of low-power laser, the SPI nano particles and the FPI nano particles can generate I-type active oxygen, and have excellent near-infrared two-region fluorescence emission performance. The preparation of the near-infrared two-region fluorescence imaging guided low-power laser triggered photodynamic therapy reagent is realized, a new method is provided for developing a low-power efficient photosensitizer, and the near-infrared two-region fluorescence imaging guided low-power laser triggered photodynamic therapy reagent has a potential application prospect in the field of biomedicine.

This invention proposes a flow field visualization experimental device and method based on *Noctiluca scintillans* biosol, belonging to the interdisciplinary field of fluid mechanics experimental measurement and bio-optics. It addresses the shortcomings of existing flow field measurement technologies in terms of economy, safety, adaptability to complex boundaries, and engineering applications of biological tracer media. It includes a biosol culture module, a flow field experimental module, a bioactivity recovery module, a biosol storage tank, and a bioactivity calibration unit. The biosol culture module includes an LED light source and *Noctiluca scintillans* culture dishes. The flow field experimental module includes an experimental flow channel, imaging equipment, and a flow field excitation model arranged in an experimental dark chamber. The bioactivity recovery module includes a light-shielding tank. The biosol storage tank is connected to the light-shielding tank. The *Noctiluca scintillans* culture dishes, experimental flow channel, and light-shielding tank are equipped with bioactivity calibration units for detecting the emission peak value of the *Noctiluca scintillans* solution. It is mainly used for flow field visualization experiments.

The invention relates to the technical field of biological optical detection, and discloses a biological measuring instrument based on a hollow pyramid delay line and an optical path calculation method.The biological measuring instrument comprises a low-coherence light source, a 3 * 3 equipartition optical fiber coupler, a reference arm module, a polarization controller, a measuring arm module, a balance detector, an FPGA data acquisition system and a notebook computer; and the measuring arm module comprises a second optical fiber collimator, a plane mirror, a dichroscope, a near-infrared LED target ring, eyes, an imaging lens group and a camera. According to the biological measuring instrument based on the hollow pyramid delay line and the optical path calculation method, the hollow pyramid delay line is adopted as a reference arm scanning device, the hollow pyramid delay line is provided with three reflecting surfaces which are perpendicular to one another, an incident beam can be strictly returned along the original path, the biological measuring instrument is not sensitive to incident angle deviation, and the mechanical stability and vibration interference resistance of a system are effectively improved; and the method is particularly suitable for application scenes with high requirements on stable measurement in a clinical environment.

Various aspects of procedures, systems, and use cases can be used to generate and display a composite real-time image, for example, by combining an initial ultrasound image in which a deep target is within the field of view (FOV) of an EBUS device with one or more subsequently acquired second ultrasound images in which the deep target is no longer within the EBUS device's field of view. In this way, the EBUS system continues to display imaged biopsy targets even when the biopsy targets are no longer within the ultrasound transducer's field of view.

An example bioptic indicia reader assembly includes: a housing having an upper housing portion and a generally upright window positioned in the upper housing portion; and a platter having a proximal edge adjacent the upper housing portion. The upper housing portion comprises a first protrusion located on a first side of a longitudinal centerline of the bioptic indicia reader assembly and a second protrusion located on a second side of the longitudinal centerline. The first protrusion comprises a first camera having a first field-of-view (FOV) having an inner first lateral boundary that extends behind and at an angle to the proximal edge of the platter and the second protrusion comprises a second camera having a second FOV having an inner third lateral boundary that extends behind and at an angle to the proximal edge of the platter.

Techniques for improving accuracy of output of an imaging system for detecting an object between a light source and a reflector are provided. The techniques include timing a sampling of a measurement of an intensity of a reflection of a light beam based on an expected processing delay associated with the imaging system circuitry. Particularly, the sampling may be timed to occur when the expected reflection intensity is at or near its greatest magnitude, so as to improve a signal-to-noise (SNR) ratio between the expected reflection and other light manipulation (noise) introduced by an environment surrounding the imaging system. An imaging system incorporating techniques herein may be implemented, for example, in a bioptic barcode reader in a retail environment to improve object detection and weight measurement accuracy by the bioptic barcode reader.

The present application relates to an assembly for cell culture and biologic optical detection, the assembly comprising a cell culture vessel having a light transparent bottom and a substrate removably attached to the light transparent bottom of the cell culture vessel, at least a portion of the surface of the substrate opposite the light transparent bottom of the cell culture vessel being light non-transparent.

This application discloses a method and detection device for determining the chlorophyll a content and spatial distribution in a single microalgal cell, relating to the field of bio-optical detection and spectral analysis technology. The method includes: acquiring the Raman spectrum and average Raman spectrum of each pixel in a preset pixel set within a preset wavenumber range for the single microalgal cell to be tested; using the average Raman spectrum or the Raman spectrum of any pixel as the current Raman spectrum; and extracting the chlorophyll a spectrum from 1521 cm⁻¹. ‑1 and 1156cm ‑1 The method involves analyzing the response value and determining the characteristic response vector of chlorophyll a; obtaining a normalized Raman feature vector based on the characteristic response vector; determining the chlorophyll a content based on the normalized Raman feature vector corresponding to the average Raman spectrum; and generating a spatial distribution image of chlorophyll a content based on the normalized Raman feature vector corresponding to the Raman spectrum of any pixel. This application achieves in-situ, non-destructive, automated, and accurate quantitative detection of chlorophyll a content in single microalgal cells.

The invention discloses a label-free cell biological chromophore detection system and method based on four-wavelength imaging, and belongs to the technical field of biological optical imaging. The system comprises a light source assembly, a multi-wavelength light beam coupling assembly, an optical microscopic imaging assembly and a computer assembly. The light source assembly emits four light beams with different wavelengths, and the light beams are adjusted to be coaxial through the coupling assembly and are endowed with different polarization directions to irradiate a biological sample. The optical microscopic imaging assembly synchronously collects under-focus and over-focus images of a sample through two polarization cameras. And the computer assembly separates each wavelength image according to the polarization direction, reconstructs a phase image by adopting an intensity transmission equation algorithm, automatically identifies the type of the chromophore based on the intensity attenuation ratio under different wavelengths, calculates the volume size of the chromophore by combining phase and amplitude information, and finally reconstructs the three-dimensional distribution of the chromophore through Z-axis scanning. According to the invention, rapid, lossless and high-precision identification and three-dimensional quantitative analysis of the cell biological chromophore are realized.

Bioptic barcode reader (100), comprehensive: a housing (105) with a generally horizontal window (115) and an upright window (140); a barcode reading device (160) arranged inside the housing (105) and having a barcode reading viewing field (165) directed out of the upright window (140) and / or the generally horizontal window (115); a first imaging device (200) which is arranged in the housing (105) and has a first viewing field (205) which is directed out of the upright window (140); a second imaging device (300) which is arranged inside the housing (105) below the first imaging device (200) and has a second viewing field (305) which is directed out of the upright window (140); wherein a first central imaging axis (210) of the first field of view (205) intersects a second central imaging axis (310) of the second field of view (305) at an angle (405) greater than or equal to 15 degrees and less than or equal to 55 degrees; and the second central imaging axis (310) of the second field of view (305) extends upwards over the generally horizontal window (115) at a second angle (315) that is greater than 0 degrees relative to the generally horizontal window (115); wherein the housing (105) comprises a lower housing part (110) and an upper housing part (125) which is attached to and extends over the lower housing part (110); wherein the first imaging device (200) is arranged in an upper third (130) of the upper housing part (125) and the first central imaging axis (210) extends downwards at a first angle (230) of greater than 0 degrees below a first plane (225) which is parallel to the generally horizontal window (115); and wherein the second imaging device (300) is arranged in a lower third (135) of the upper housing part (125) and the second central imaging axis (310) extends upwards over an upper surface (40) of the generally horizontal window (115) at a second angle (315) greater than 0 degrees.

This invention provides a method and system for reconstructing three-dimensional chlorophyll a concentration in the ocean based on deep learning. The method first acquires multi-source input data from the target sea area, including bio-optical parameters, vertical physical profile data, and geographic coordinates. Then, the multi-source data is preprocessed and feature fused to form a unified-dimensional input feature vector. This vector is then input into a trained deep neural network model, whose hidden layers include a spatial attention mechanism module and a residual correction structure module, to output predicted chlorophyll a concentration values ​​at multiple discrete depth layers. Finally, a three-dimensional chlorophyll a concentration field is reconstructed based on these predicted values. This invention integrates multi-source heterogeneous data and, by introducing an attention mechanism and residual structure, significantly improves the accuracy and spatiotemporal characterization capability of three-dimensional reconstruction of complex nonlinear marine ecological processes, providing reliable technical support for marine primary productivity estimation, carbon flux research, and ecosystem dynamic monitoring.

The invention discloses an atmospheric correction method suitable for a lake. The atmospheric correction method comprises the following steps: S1, selecting a lake water area as a research area; s2, adopting L1-level data of a water color remote sensing satellite image to calculate a total image radiance minimum value to obtain a global dark pixel; s3, taking a stable land feature reflection target as a fixed reflection area, and averaging the multi-year reflectivity data to obtain stable reflectivity; s4, for the water color remote sensing satellite image of the research area, respectively performing land masking, cloud masking and saturated pixel masking by adopting a threshold method; s5, in combination with an atmospheric correction formula and the parameters obtained in the steps S2 to S4, calculating to obtain a rough estimation initial value of the remote sensing reflectance of the water body; s6, constructing a bio-optical model based on the inherent optical properties of the water body, and minimizing a loss function through a spectrum optimization algorithm to obtain an optimized final value of the remote sensing reflectance ratio of the water body; and S7, through comparison with a mature satellite default correction result and on-site actual measurement verification, the correction precision is evaluated so as to carry out atmospheric correction result verification.

This invention proposes a method and system for regional monitoring and early warning of offshore wind farms based on multi-source information, belonging to the field of offshore wind farm safety monitoring technology. The method includes: collecting vibration response data of pile foundation structures, seabed topography data, submarine cable tension data, and marine environmental parameters through a multi-type sensor network; acquiring bio-optical response signals through a biosensor monitoring unit; fusing the multi-source information using a multi-stage process including spatiotemporal registration, feature extraction, correlation mapping, and conflict resolution to generate a reliable comprehensive sensing result; performing trend extrapolation based on a neural network predictive analysis model to generate predicted data on pile foundation scour depth and submarine cable displacement; and generating an early warning signal and initiating a response through an early warning level mapping mechanism. This invention integrates physical and biological response information, significantly improving the accuracy, reliability, and timeliness of monitoring and early warning.

This invention relates to the field of anti-counterfeiting and traceability technology for traditional Chinese medicine (TCM) materials, and discloses an AI digital fingerprint construction method and system for synthetic biological characteristics of TCM materials. The method includes: acquiring a feature dataset; performing bio-optical cross-modal mapping to obtain a digital fingerprint and constructing a four-dimensional state set; performing dynamic evolutionary offset judgment to obtain a verification identifier set; obtaining a distributed confirmation function through mathematical consistency verification and constructing a dynamic evolutionary graph; performing physical sorting and control based on the graph; generating a value disposal certificate and constructing a biological performance credit index. This invention solves the counterfeiting problems caused by code-object separation and feature isomorphism, penetrates homogeneous noise to achieve stable identification of TCM material biological characteristics, and ensures reliable circulation in the supply chain.