118 results about "Isotopologue" patented technology

The invention discloses a method and system for increasing judgment accuracy of monoisotopic peaks. The method comprises the following steps: according to selected tandem mass spectrums, determining candidate isotopic peak clusters; according to the similarity and the strength ratio of the chromatographic outflow curves of the candidate isotopic peak clusters, determining the start and stop of the isotopic peak clusters; according to the start and stop of the isotopic peak clusters, determining the quality of the monoisotopic peaks; and judging whether the monoisotopic peaks of the tandem mass spectrums are not determined or not, if yes, returning and selecting a new tandem mass spectrum to determine a candidate isotopic peak cluster, and if not, ending.

A method for absolute protein or peptide quantitation by mass spectroscopy. A sample containing a protein or peptide of interest is prepared for mass spectroscopy analysis. The sample is subjected to mass spectroscopy analysis at low resolution whereby a single additive mass spectroscopy peak is obtained, then is subjected to high resolution mass spectroscopy analysis whereby a plurality of mass spectroscopy peaks are obtained. The intensity of each of the plurality of mass spectroscopy peaks is quantitated either by comparison to an internal standard set, or by using a standard curve generated for each isotopologue set. Quantitation using a standard curve enhances quantitation across a dynamic range of analyte.

The present invention relates to an isotopologue of Compound 1 substituted with deuterium at the methylene carbon of the benzodioxol ring. The isotopologues of this invention selective serotonin reuptake inhibitors (SSRIs) and possess unique biopharmaceutical and metabolic properties compared to Compound 1. They may also be used to accurately determine the concentration of Compound 1 in biological fluids and to determine metabolic patterns of Compound 1 and its isotopologues. The invention further provides compositions comprising these deuterated isotopologues and methods of treating diseases and conditions that are responsive to increased neuronal serotonin transmission, alone and in combination with additional agents.

The invention relates to a method for production of a radio-isotope (4) from a target (3), containing a precursor (1) of said radio-isotope (4), using a beam of accelerated particles, comprising the following method steps: preparation of a target (3), containing the precursor (1) of the radioisotope (4), irradiation of said target (3) within an irradiation chamber (10) with a beam of accelerated particles in order to induce the transmutation of the precursor (1) into the radio-isotope (4), heating said target (3) in order to bring about the efflux of the radio-isotope (4) from the target (3), collection of said radio-isotope (4), extracted as a gas and condensation of said radio-isotope (4) into a solid or liquid. The invention further relates to a device for carrying out the above method and use of the device and method for the production of palladium 103 from rhodium 103.

The invention discloses application of a compound as shown in a formula I, or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof, or a solvate thereof, or a crystal form thereof, or an isotopologue thereof in preparing a sensitizer for a tumor immunotherapeutic drug, wherein R1-R3 are independently selected from hydroxyl, C1-6 alkoxy, substituents as shown in a formula II or cis-isomers thereof; and R4 and R5 are independently selected from hydrogen, halogen, C1-6 alkyl, hydroxyl or C1-6 alkoxy. A pharmacological experiment result verifies that the chlorogenic acid and the derivative thereof which are combined in use with the tumor immunotherapeutic drug can better play a role of killing tumor cells, and the sensitizer as the tumor immunotherapeutic drug has wide clinical application prospects.

The invention relates to a unimodal 87 Rb isotopic atomic filter used for laser frequency stabilization and a method for filtering by adopting the atomic filter. The filter consists of components of an external cavity laser 1, an optical isolator 2, a first semipermeable semi-reflective mirror 3, a second semipermeable semi-reflective mirror 4, a first high reflectivity mirror 5, a natural rubidium cell 6 and the like. According to the unimodal 87 Rb isotopic atomic filter used for laser frequency stabilization and the filter method thereof, by using the Faraday anomalous dispersion effect of isotopic 87 Rb ground state atoms in a magnetic field, a uniform magnetic field is generated through a magnetic field source, such as a permanent magnet, and the laser and atoms are interacted, so the laser polarization direction is changed. The laser transmission polarization direction is limited by two polarizing prisms, the light wave with specific frequency is chosen, and the goal of filtering is achieved. A system is enabled to be in a good working condition through a temperature control system. The unimodal atomic filter has the advantages of simple structure, high filtering performance, work stability, long service life and the transmission rate of being more than 78.0%. The unimodal 87 Rb isotopic atomic filter used for laser frequency stabilization and the filter method thereof have important significance in the experiment with interaction between light and atoms.

The method typically uses spontaneous gamma rays from radioisotopes, either cadmium-109 at 88 keV or cobalt-57 at 122 keV, detected with NaI(Tl) or HPGe. After a two-part split, detection pulses are windowed for the characteristic gamma ray pulse amplitude and measured in coincidence. By using high resolution detectors and gamma rays that match the part of the spectrum where the detector has a high photoelectric effect efficiency, coincidence rates are found to substantially exceed the chance rate. This refutes the quantum mechanical prediction of energy quantization. This unquantum effect implies that photons are an illusion, and is explained by an extension of the abandoned loading theory of Planck to derive the photoelectric effect equation. In scattering gamma rays in a beam splitter geometry, changes in response to magnetic fields, temperature, and crystal orientation are tools for measuring properties of atomic bonds. With detectors in a tandem geometry where the first detector is both scatterer and absorber, tests reveal properties consistent with a classical gamma ray model. The method has also shown use in discovering that different crystalline states of the gamma ray source change the extent coincidence rates exceed chance, whereas conventional gamma ray spectroscopy shows no substantial dependence upon these applied variables.

The present invention relates to an aryloxypropanamine containing one or more deuterium or ¹³C in place of a hydrogen or carbon, respectively. These isotopic aryloxypropanamines of the invention are inhibitors of serotonin and norepinephrine uptake and possess unique biopharmaceutical and pharmacokinetic properties compared to the responding light atom isotopologues. The invention further provides compositions comprising these isotopic aryloxypropanamines and methods of treating diseases and conditions linked to reduced neurotransmission of norepinephrine and/or serotonin. It further provides methods for using these isotopic aryloxypropanamines to accurately determine the concentration of the light atom isotopologues in biological fluids and of studying the metabolism of the light atom isotopologues.

The invention relates to the method of treating metabolic syndrome in a mammal in need thereof comprising a step of administering to said mammal an effective amount of water comprising from 99.76 to 99.99 molecular % of isotopologue ¹H₂¹⁶O. Further, invention relates to the medical food for treating metabolic syndrome in a mammal in need thereof which comprises water comprising from 99.76 to about 99.99 molecular % of isotopologue ¹H₂¹⁶O. Further, invention relates to the use of water comprising from about 99.76 to about 99.99 molecular % of isotopologue ¹H₂¹⁶O for the manufacture of a medical food for treating metabolic syndrome in a mammal in need thereof.

A method of characterising a sample from spectrometric data using calculation of spectral distance values is disclosed, for use in the field of mass spectrometry. Molecular formula assignment of peaks in mass spectral data is difficult and time-consuming, and the invention provides a computer implemented method of finding a most likely elemental composition of a measured spectral peak of interest. The method analyses isotopic peaks in a portion of the spectrum, using both their mass positions and intensities, to determine a spectral distance between those peaks and isotopic peaks of a candidate composition, finding peaks that match (140). A pattern spectral distance is determined (150) to provide a measure of the correspondence between a set of those peaks in the measured spectrum and peaks of each of a number of candidate compositions. The spectral fit is used to determine a most likely candidate composition.

The present invention describes a method of selective peptide isolation for the identification and quantitative analysis of proteins in complex mixture. The method comprises the selective isolation from every protein of those peptides that neither contain arginine nor histidine (NHNR peptides), and the determination of the relative concentrations of one or several proteins in different samples from the ratio between the areas of the estimated theoretical spectra for the NHNR peptides labeled with different isotopes in each sample. The determination of the relative concentration of proteins is valid for any type of isotopic label of the NHNR peptides. The method avoids the separation and purification of the proteins present in a complex mixture, and the analysis of all peptides generated from the enzymatic digest of the samples. The method is applicable to the identification of proteins with vacunal, therapeutic and diagnostic aims.

The present invention is a novel method for removing tritium oxide contamination from a solution with water. The method captures the tritium oxide in a much smaller volume suitable for economical disposal. In so doing the original water is decontaminated of the tritium oxide and may be discharged.

Provided herein are methods of treating, preventing, managing, and/or ameliorating leukemia or myelodysplastic syndrome comprising administering 2-(4-chlorophenyl)-N-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)-2,2-difluoroacetamide or a stereoisomer or mixture of stereoisomers, an isotopologue, pharmaceutically acceptable salt, tautomer, solvate, hydrate, co-crystal, clathrate, or polymorph thereof to a patient.

Disclosed is a process and a system for recovery of isotopologues of water from an aqueous liquid stream containing dissolved impurities.

The method shows how to violate predictions of quantum mechanics for matter. For light, the method has been disclosed in patent application Photon Violation Spectroscopy. The methods are different in specifying different methods for light and matter. For matter, the method typically uses the single 5.5 MeV alpha (He++) emitted from the radioisotope Americium-241 in spontaneous decay, a thin gold foil beam splitter, and two surface barrier alpha detectors. The detectors deliver a characteristic electrical pulse with amplitude proportional to matter wave energy. A circuit reads the coincidence rate and singles rates of pulses from the two detectors. Quantum mechanics predicts that the particle would go one way or the other at the beam splitter, and coincident detections of pulses characteristic of such a particle would occur only at an easily calculated chance rate. However, the method at hand shows such characteristic pulses occur in coincidence at a rate greatly exceeding chance. By exceeding chance the method demonstrates surpassing a binding energy threshold and predictions of quantum mechanics. The degree above chance is a new measure in fundamental physics and is usable as a material science probe of the beam splitter. An apparatus specially designed to test for the absence of true coincidences and then perform a beam splitting test to show split-beam coincidences becomes useful in applying the method of Particle Violation Spectroscopy to material science. Fundamental discoveries in physics have been made with this method; therefore it is a method of discovery in physics.

The present invention relates to dietary supplements, medical foods, and pharmaceutical compositions comprising an aqueous solution of salt of choline, wherein solution comprises a deuterium depleted water having content of deuterium from about 90 to about 135 ppm and ¹H₂¹⁶O isotopologue up to 99.759%, in particular, the invention relates to an aqueous solution of succinate salt of choline, wherein the aqueous solution comprises said deuterium depleted water.

The invention relates to the field of stable isotope analysis technology of trace gas, in particular to a sample collection method and a collection device for measuring abundance of <15/14>N isotope of N2O discharged by plant. The method comprises the following steps of: disposing a plant sample to be measured in a gas collection device, filling artificial air free of N2O from a collection hole provided on the collection device to exchange air, collecting the gas sample in the device in 20 to 60 min after closing the sample collecting hole, and measuring the value of delta<15>N of N2O in the gas sample by a stable isotope ratio mass spectrometer. The gas collection device comprises a component with variable shape and volume during air pumping process and a gas collector, wherein the plant sample to be detected is accommodated in the sealed component; the gas sampling hole is provided on the component; and a gas collector is hermitically connected with the component through the gas sampling hole. The inventive collection device and the measuring method can conveniently and accurately measure the abundance of stable isotope <15/14>N of N2O discharged by a plant system.