The invention provides a laser-driven macroscopic liquid flow device and method based on optical fiber which is used for solving the problem that macroscopic liquid flow cannot be produced through simple combination of a photoacoustic effect and a sound wave driving fluid effect. According to the laser-driven macroscopic liquid flow device and method based on the optical fiber, nanometer gold particles are injected into one end face of the optical fiber by adopting an injection technology, and fixed and immersed in a driven solution, meanwhile, a nanosecond laser pulse is coupled into the optical fiber from the other end face of the optical fiber, and the laser pulse interacts with the nanometer gold particles injected into the optical fiber; the nanometer gold particles produce ultrasoundunder the effect of laser due to the photoacoustic effect, and meanwhile, a liquid is driven to flow due to the sound wave driving fluid effect; a fixed liquid-liquid interface and a liquid flow channel are needed, special requirements for the flowing liquid and the environment do not exist, the laser-driven macroscopic liquid flow device and method based on optical fiber is suitable for any liquids, tenability of the flow speed and direction of the driven liquid can be achieved, flowing of the driven liquid is monitored on line in real time by adopting a CCD, the control accuracy is improvedgreatly, and operation is convenient and easy.