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O-NITROTOLUENE is toxic by inhalation, ingestion and skin aborption, targeting the blood, central nervous system, skin, and gastrointestinal tract. Symptoms include, anoxia, weakness or dizziness, nausea and vomiting. If it contacts the eye, the eye should be irrigated immediately. If it contacts the skin, the area should be washed with soap.
An o-nitrobenzaldehyde and a method for synthesizing the same
The application discloses o-nitrobenzaldehyde and a synthesis method thereof, and belongs to the technical field of medical intermediates. The synthesis method comprises the following steps: dissolving o-nitrotoluene, dibromohydantoin and azobisisobutyronitrile in mixed organic solvents to perform a bromination reaction, then performing filtration, impurity removal, extraction and organic phase drying in sequence, and separating o-nitrodibromobenzene; adding the o-nitrodibromobenzene into a DMSO solution, adding calcium carbonate to perform an oxidation reaction, then performing filtration, extraction, organic phase drying and purification and decoloration in sequence, and obtaining o-nitrobenzaldehyde. The o-nitrobenzaldehyde is obtained through a bromination oxidation two-step reaction, the synthesis method has the advantages of simple process, low cost, small pollution and high product yield.
Owner:SHAANXI UNIV OF SCI & TECH