The invention discloses a Z-pinch driven fusion-fission hybrid energy reactor. The Z-pinch driven fusion-fission hybrid energy reactor comprises a Z-pinch inertial confinement fusion reactor core, a subcritical fission cladding and energy output system, and a tritium production cladding and deuterium-tritium circulation system. The fusion reactor core comprises a fusion load, fusion targets, a fusion driver and a fusion target chamber supporting continuous operation of fusion. The subcritical fission cladding and energy output system comprises a subcritical cladding, a cooling loop, a steam generator and a voltage stabilizer. The tritium production cladding and deuterium-tritium circulation system comprises a tritium production cladding, a reactor core residual tritium recovery system and an out-of-reactor tritium factory. According to the Z-pinch driven fusion-fission hybrid energy reactor, the inertial confinement fusion reactor core scheme based on the integrated ignition technology is high in realizability and reliable in performance, depleted uranium and thorium can be fully utilized, and therefore the fission resource utilization efficiency is improved; the whole fusion-fission hybrid energy reactor is reasonable and balanced in design, the subcritical cladding is driven through the Z-pinch fusion reactor core, and long-term sufficient clean electrical energy can be provided.