The invention relates to an automatic pressing production line for large-scale explosive powder columns, which includes a hydraulic press consisting of an upper beam, an upper return cylinder, an upper cylinder slider, an upper punch, a middle beam equipped with a die sleeve, and a lower beam. The characteristics are: It includes an automatic weighing and feeding device, a powder smoothing device and an automatic discharging device arranged on the side of the hydraulic press. The upper part of the lower beam is equipped with a lower return cylinder, which is connected with the slider of the lower belt cylinder, and the lower belt cylinder slides The block is equipped with a lower punch, an automatic vacuum device is provided at the lower part of the upper cylinder slider, and a mechanical limit device is provided on the upper cylinder slider and the lower cylinder slider. The advantages are: this production line can realize the fully automatic operation of explosive column feeding, smoothing, two-way pressing and discharging, which can not only greatly reduce the labor intensity of operators, improve the production efficiency of large-tonnage hydraulic presses, avoid potential safety hazards, and It can reduce the air bubbles in the powder column during the pressing process, improve the mass density uniformity and precision of the powder column, and ensure the product quality.