The invention discloses a damp-proof and sound-insulation building plate. The damp-proof and sound-insulation building plate comprises an echo-prevention foam layer, a waterproof layer, a thermal insulation layer, a sound insulation layer and a bonding layer. The interior of the sound insulation layer is sealed to form a vacuum chamber, the whole waterproof layer is of an inner-sunken type structure, force bearing partition plates are further arranged in an inner cavity of the waterproof layer at equal intervals, and the edges of the force bearing partition plates and the waterproof layer areof parallelly mounted structures; and the surface of the waterproof layer is coated with a waterproof coating, a positioning hole is formed in the bonding layer, the positions between the force bearing partition plates and the waterproof layer are filled with drying agents, and a plurality of elastic buffering pieces are symmetrically mounted between every two adjacent force bearing partition plates. According to the damp-proof and sound-insulation building plate, the appearance is excellent, durability is achieved, the structure is stable, mounting is convenient, thermal insulation is achieved, the waterproof effect is good, the sound insulation effect is good, the service life is long, and the cost is low.