The invention discloses a modified EH550 super-thick steel plate for marine engineering and a manufacturing method thereof. The steel contains 0.08% to 0.15% of C, 0.20% to 0.55% of Si, 0.80% to 1.35%of Mn, less than or equal to 0.01% of P, less than or equal to 0.03% of S, 0.04% to 0.08% of V, 0.015% to 0.45% of Als, 0.003-0.015% of N, 0.50-0.90% of Ni, 0.20-0.40% of Cr, 0.002-0.03% of Mo, 0.02%to 0.05% of Nb, 0.20-0.40% of Cu, less than or equal to 0.04% of Ti, and the balance of Fe and unavoidable impurities. The method employs two-stage controlled rolling, the first-stage rolling temperature is 1100-1150 DEG C, the one-stage finishing rolling temperature is 990-1130 DEG C, the second-stage rolling temperature is 700-780 DEG C, and the final rolling temperature is 680-750 DEG C. The heat treatment method of quenching before sub-quenching is used, and after quenching, the steel plate is tempered, and the steel plate having a thickness of 80-100 mm is obtained. The impact toughnessof a core is more than 200J, and the comprehensive performance is uniform at different positions.