The invention discloses a high-resistance electrophoretic aluminum profile being resistant to cracking caused by bending and a preparation method of the aluminum profile, and relates to the technicalfield of aluminum alloy materials. A substrate material of the aluminum profile comprises the following elements in percentage by weight: 0.46-0.55% of Si, 0.68-0.78% of Mg, 0.25-0.33% of Fe, 0.12-0.18% of Mo, 0.22-0.30% of Mn, no more than 0.05% of Cr, no more than 0 .05% of Cu, no more than 0.10% of Zn, and the balance Al and inevitable impurities, wherein the content of a single impurity is lower than or equal to 0.05%, the total content of the impurities is lower than or equal to 0.15%, and the ratio of Mg to Si in the substrate material is higher than or equal to 1.43 and lower than or equal to 1.60. The preparation method comprises the following steps: smelting, homogenization treatment, primary extrusion, secondary extrusion, aging treatment, anodic oxidation treatment and electrophoretic painting. Through the interaction among all the alloying elements, the aluminum profile disclosed by the invention is high in toughness and plasticity; during the preparation process, crystal grains become finer and more uniform through two extrusion forming operations, the strengthening effect is good, both the mechanical properties and the processing properties of such an alloy are obviously improved, and the possibility of cracking and other phenomena during the bending deformation processing process is low; and accordingly, the aluminum profile is resistant to cracking caused by bending and high in resistance.