The invention relates to a dustproof host with a mistaken touch prevention function. The dustproof host comprises a main body, radiating ports, a fan and a power key, a dustproof mechanism and a protection mechanism. The dustproof mechanism comprises a dustproof net, a mounting assembly, a supporting plate, a mounting bearing, a driving shaft, a rotating rod, a cleaning brush, at least two fan blades, two supporting rods and two springs. The protection mechanism comprises an annular air bag, a cover plate, a rotating shaft, an air conveying pipe, an air cylinder, a piston block, an elastic rope, two torsion springs and two connecting bearings. The mounting assembly comprises at least two columnar notches and at least two limiting columns; according to the dustproof host with the mistaken touch prevention function, through the dustproof effect of the dustproof mechanism, the probability that dust enters the host is reduced, the practicability of the host is improved, through the protection effect of the protection mechanism, the probability that a power key is mistakenly operated is reduced, and the practicability of the host is further improved.