The invention relates to an infantile Qishen reinfection granule and a preparation method thereof. The infantile Qishen reinfection granule is prepared from 323.3 to 343.3 g of roasted astragalus membranaceus, 190.0 to 210.0 g of radix salviae miltiorrhizae, 190.0 to 210.0 g of bran-fried rhizoma atractylodis macrocephalae, 190.0 to 210.0 g of pericarpium citri reticulatae, 323.3 to 343.3 g of radix pseudostellariae, 190.0 to 210.0 g of radix paeoniae rubra, 123.3 to 143.3 g of rhizoma chuanxiong and 190.0 to 210.0 g of vinegar-processed endothelium corneum gigeriae galli. The infantile Qishen reinfection granule is a qi-tonifying, blood-activating and spleen-activating formula, the treatment effect on infantile recurrent respiratory tract infection is verified, the effect is remarkable, the formula consists of eight traditional Chinese medicines such as roasted astragalus membranaceus, radix pseudostellariae, radix salviae miltiorrhizae and ligusticum wallichii, and the formula pays attention to qi-tonifying, blood-activating and spleen-activating and highlights the traditional Chinese medicine theory of 'collaterals entering after long illness'; the treatment rule of promoting blood circulation to remove meridian obstruction is realized while the body resistance is strengthened; and clinical tests for many years show that the curative effect is exact.