The invention provides a large-scale energy storage SOC balance coordination control system and method. The system comprises a first bus, a second bus, a third bus, a fourth bus, at least one photovoltaic power generation unit, at least one wind power generation unit, at least two loads, a first line impedance, a second line impedance, a third line impedance, a fourth line impedance and N lithiumbattery boxes. In order to adjust the charging and discharging power of each battery according to the properties of the batteries with different capacities, the system achieves the purpose that the SOC tends to be consistent, has certain resistance to power grid disturbance caused by frequent load switching, and maintains the stability of each bus voltage. Different reference voltage regulation coefficients are distributed to batteries with different capacities, and the corresponding change ranges are given, thereby achieving the reasonable distribution of the charging and discharging power, reducing the loss of the battery and prolonging the service life of the battery. Meanwhile, the SOC can be kept consistent for a long time through reference adjustment coefficient adjustment when all batteries reach the same SOC.