A special-shaped beam-column steel frame with sandwich panels, the frame is supported by special-shaped steel columns and special-shaped steel beams, each side of the special-shaped steel columns and special-shaped steel beams is covered by wall prefabricated panels, and a pair of wall prefabricated panels The steel connectors are fixed to form the wall, and the special-shaped steel columns are set at the corners of the wall and the middle of the straight wall; special-shaped steel beams are set on the top of the wall; the cross-sectional shapes of the special-shaped steel columns are L-shaped, T-shaped, ten Shaped, straight; the cross-sectional shape of the special-shaped steel beam is that there are protruding ears on both sides or one side of the rectangular steel pipe. The building steel frame of the present invention can realize all factory prefabrication, on-site dry construction, and the steel beams and columns are covered by wall prefabricated panels, which has extremely strong fireproof, anti-corrosion, heat preservation and energy-saving performance, and the wall has no protruding beams and columns , The structure is beautiful, and the effective use area is maximized. The construction process is fast, convenient, and low in cost, and the prefabricated parts are unitized, which is more flexible and easy to transport.