The invention relates to the technical field of computational fluid
mechanics and biological microfluidic design, in particular to a
model order reduction method for rapid optimization of a
circulating tumor cell (CTC) sorting structure, which comprises the following steps of: constructing a three-dimensional full-order computational fluid
mechanics model by collecting channel geometric structure parameters and fluid working condition parameters, and generating a training
data set; organizing a flow field snapshot into a
matrix form, extracting a dominant mode, constructing a low-dimensional
modal space by taking the dominant mode as a base vector, establishing a low-dimensional ordinary differential model through Galerkin projection, and training a parameter-
modal coefficient mapping relation by adopting a deep neural network to form a complete reduced-order model; and finally, constructing a multi-objective
optimization problem based on the reduced-order model, carrying out optimization iteration by adopting an
evolutionary algorithm, and returning an optimization result to the full-order model for
verification, so that rapid optimization design of the CTC sorting structure is realized, and an
effective solution is provided for
intelligent design of a biomedical microfluidic device.