39 results about "Insulin blood" patented technology

The invention defines interdependent biofactors and biomolecules, and clinically useful formulations that are comprised of them. The active agents are demonstrated to be complementary in their physiologic functions especially as these relate to the quenching of free radicals and to the support of endothelial physiology, the reduction of hyperinsulinemia and improvements in vascular health. The active components of the invention are selected for inclusion in precise combinations specifically because they improve these various conditions and physiological functions, and by so doing reduce a variety of risks associated with hearing loss and tinnitus. The resulting enhancement of general systemic vascular health, improvement in local VIIIth nerve vascular health, modulation of conditions surrounding blood fluid dynamics, the consequences of hyperinsulinemia, and improvements in free radical defenses, all reduce the potential for cochlear hair cell death and VIIIth nerve atrophy, and the hearing loss and possible deafness that accompany them.

The present invention includes peptidomimetic compound compositions and methods of making and using peptidomimetic compounds to modulate the activity of a peptide receptor for the treatment of one or more of hyperglycemia, insulin resistance, hyperinsulinemia, obesity, hyperlipidemia, hyperlipoproteinemia or other symptoms that relate to the function of the targeted receptor. The peptidomimetic includes an oligo-benzamide compound having at least three optionally substituted benzamides.

The invention provides a conjugate comprising a biomolecule linked to a fatty acid via a linker wherein the fatty acid has the following Formulae A1, A2 or A3:

The invention discloses an insulin pump with a dynamic closed-loop control in the field of medical equipment. The insulin pump comprises an administration mechanism, a driving mechanism, a detection mechanism and a dynamic control module, wherein the administration mechanism is connected with the insulin pump and transmits insulin injection amount information; the driving mechanism is connected with an injection unit of the insulin pump, and transmits and controls the injection amount information; the detection mechanism is connected with a glucometer and transmits human body blood glucose information; and the dynamic control module is connected with the driving mechanism of the insulin pump and transmits insulin-blood glucose level control information. The insulin pump with the dynamic closed-loop control can effectively reduce the unstabilizing factors due to a complex blood glucose system and has the relatively nice robustness after simulation testing. The insulin pump can control the blood glucose level of the diabetics and the injection amount of the insulin in time through model prediction and iterative control, so that the blood glucose level of the diabetics tends to be stable; and therefore, the effect of the insulin pump to control the injection automatically is achieved.

The present invention is directed to certain novel triazole compounds represented by Formula I and pharmaceutically acceptable salts, solvates, hydrates, and prodrugs thereof. The present invention is also directed to methods of making and using such compounds and pharmaceutical compositions containing such compounds to treat or control a number of diseases mediated by PPAR such as glucose metabolism, lipid metabolism and insulin secretion, specifically Type 2 diabetes, hyperinsulemia, hyperlipidemia, hyperuricemia, hypercholesteremia, atherosclerosis, one or more risk factors for cardiovascular disease, Syndrome X, hypertriglyceridemia, hyperglycemia, obesity, and eating disorders.

This invention provides compounds, compositions, and methods for treating a disorder selected from cancer, hyperinsulinemia, hypoglycemia, hyperinsulinemia with hypoglycemia, atypical Parkinson's disease, Huntington's disease, multiple systems atrophy, GM3 synthase deficiency, GM2 synthase deficiency or tauopathy.

The invention relates to functional edible oil as well as a preparation method and application thereof. The functional edible oil is formed by performing ternary ester exchange on medium- carbon-chain glyceride, linoleic acid grease and linolenic acid grease. On the basis of the mass of fatty acid, the mass ratio of medium-carbon-chain fatty acid in the medium-carbon-chain glyceride to long-carbon-chain fatty acid in the linoleic acid grease and the linolenic acid grease is 2.3-4.0, and the mass ratio of linoleic acid to linolenic acid in the long-carbon-chain fatty acid is 0.5-1.0. The addition amount of the functional edible oil in foods is greater than or equal to 18.00%. The functional edible oil can significantly improve in-vivo glucose and lipid metabolism disorder, balance and supplement in-vivo necessary and functional fatty acids, and rapidly supplement energy, has a freezing point lower than 7.5 DEG C, can meet consumers, particularly, dietary and nutritional requirements of patients with metabolic syndromes such as overweight, obesity, fatty liver, hyperlipidemia, hyperglycemia, hypertension, hyperblood viscosity, hyperuricemia and hyperinsulinemia and athletes can be met, and the functional edible oil can be widely applied to foods and special medical application industries.

The invention discloses application of triacetyl-3-hydroxyphenyl adenosine, as shown in Formula (I), in preparing medicines for preventing, relieving or treating insulin resistance and related diseases, wherein the insulin resistance related diseases include type II diabetes, abnormal glucose tolerance, hyperinsulinemia, impaired glucose tolerance, hypertension, coronary disease, obesity and non-alcoholic fatty liver disease. Specifically, the triacetyl-3-hydroxyphenyl adenosine disclosed by the invention can improve the insulin sensitivity of peripheral tissues and the glucose tolerance of a body and the triacetyl-3-hydroxyphenyl adenosine can reduce insulin content, so that insulin resistance is improved (as shown in the Description).

The invention relates to functional structure oil, which is formed by carrying out quaternary ester exchange on camphor tree seed kernel oil, caprylin, linoleic acid grease and linolenic acid grease. The preparation method comprises the following steps: directly carrying out quaternary ester exchange on camphor tree seed kernel oil, caprylin, linoleic acid grease and linolenic acid grease at proper temperature and stirring intensity by taking lipase as a catalyst, and carrying out molecular distillation purification to obtain the functional structure oil. The functional structure oil can significantly improve in-vivo glucose and lipid metabolism disorder, balance and supplement in-vivo necessary and functional fatty acids, and quickly supplement energy, and can meet the requirements of consumers. Particularly, the dietary and nutritional requirements of patients with metabolic syndromes such as overweight, obesity, fatty liver, hyperlipidemia, hyperglycemia, hypertension, hyperblood viscosity, hyperuricemia and hyperinsulinemia and athletes can be met, and the food can be widely applied to the industries of grease powder, milk tea, meal replacement powder, health food, sports nutritious food and food for special medical purposes.

Mouse proteins differentially expressed in serum, in comparisons of normal vs. hyperinsulinemic, hyperinsulinemic vs. type 2 diabetic, and normal vs. type 2 diabetic white adipose tissue have been identified, as have corresponding human proteins. The human molecules, or antagonists thereof, may be used for protection against hyperinsulinemia or type 2 diabetes, or their sequalae.

The invention discloses special grease base oil for a functional food as well as a preparation method and application of the special grease base oil. The special grease base oil is formed by performing ternary ester exchange on medium-carbon-chain glyceride, high-melting-point fat and linolenic acid grease, and performing ternary ester exchange on the medium-carbon-chain glyceride, the high-melting-point fat and the linolenic acid grease under the conditions of temperature and stirring intensity by taking lipase as a catalyst, so as to obtain the special grease base oil for the functional food in one step. The special grease base oil for for the functional food is wide in melting range, can remarkably improve in-vivo glucose and lipid metabolism disorder, balance and supplement in-vivo necessary and functional fatty acids and quickly supplement energy, can meet the requirements of consumers, particularly, dietary and nutritional requirements of patients with metabolic syndromes such as overweight, obesity, fatty liver, hyperlipidemia, hyperglycemia, hypertension, hyperblood viscosity, hyperuricemia and hyperinsulinemia and athletes can be met, and the special grease base oil can be widely applied to grease powder, margarine and sports nutritional foods.

The invention discloses a method for inducing type 2 diabetes animal model through low-temperature and dietary rhythm regulation and control. By combining the regulation and control of a low-temperature environment with the change of the dietary rhythm of a feeding feed or independently through the change of a dietary rhythm of the feeding feed, or through only the change of the dietary rhythm ofthe feeding feed, the animal is induced to form type 2 diabetes animal model with weight gain, hyperlipidemia, hyperglycemia, hyperinsulinemia and insulin resistance as main markers. Experimental research results show that SD rats can be induced to form main markers of type 2 diabetes such as weight gain, hyperlipidemia, hyperglycemia, hyperinsulinemia and insulin resistance by low-temperature environment and night time-limited diet, the diversity of intestinal microorganisms can be remarkably reduced, the morbidity mode is close to that of human type 2 diabetes, and the constructed diabetes animal model can be used for studying a morbidity mechanism of type 2 diabetes, searching related targets of early diagnosis, and researching and developing treatment drugs and prevention and treatmentmethods.

The invention provides a COX18 polypeptide with biological activity. An amino acid sequence of the polypeptide is as shown in SEQ ID NO. 1: LLPAGWILSH LETYRRPE. The invention further provides a methodfor synthesizing the COX18 polypeptide through a chemical synthesis method, namely an Fmoc method as well as application, and the polypeptide is applicationd for preparing drugs which inhibit sugar induced insulin secretion, resist insulin tolerance, resist hyperinsulinemia and reduce body weight. The invention finds a novel COX18 polypeptide which is 52-69th part of human cytochrome c oxidase 8A, which is different from the precious porcine sequence. Compared with the previous sequence, the sequence has 38.88% of different amino acid. Moreover, the sequence is humanized, and has better homology, fewer immunoreactions and side effects while being applied to a human body.

The invention provides a human umbilical cord mesenchymal stem cell culture medium, a human umbilical cord mesenchymal stem cell injection, a preparation method and application of the human umbilical cord mesenchymal stem cell culture medium and the human umbilical cord mesenchymal stem cell injection in preparation of drugs for treating cerebral apoplexy. The human umbilical cord mesenchymal stem cell culture medium comprises a basic culture medium, vitamin C, insulin, platelet-derived growth factors, epidermal growth factors, basic fibroblast growth factors, beta-mercaptoethanol, SAG, folic acid, hypoxia inducible factor-1, protoporphyrin cobalt and simvastatin. The SAG, the hypoxia inducible factor-1, the protoporphyrin cobalt and the simvastatin are creatively combined to be used for preparing the human umbilical cord mesenchymal stem cell culture medium, and the four components are matched with one another, so that the human umbilical cord mesenchymal stem cell culture medium has a remarkable synergistic interaction effect in the aspect of promoting proliferation of umbilical cord mesenchymal stem cells. The human umbilical cord mesenchymal stem cells obtained through culture are high in multiplication capacity, the prepared human umbilical cord mesenchymal stem cell injection can be directly used for treating cerebral apoplexy after resuscitation, and the human umbilical cord mesenchymal stem cell injection has important application value.

Compounds, compositions and methods are provided for mitochondrial modulation. The subject mitochondrial modulator compounds generally include a head group linked to a charged moiety. In certain cases, the head group is a heterocyclic or a heteroaryl group. Aspects of the subject methods include a method of modulating mitochondria. Aspects of the subject methods include treating a subject having a metabolic syndrome-related disease or a symptom thereof by administering to the subject a therapeutically effective amount of a subject compound. In certain cases, the disease is selected from hyperlipidemia, type 2 diabetes, fatty liver disease, obesity, cardiovascular disease and stroke. In certain cases, the symptom is selected from abdominal obesity, insulin resistance, hyperinsulinemia, high levels of blood fats, increased blood pressure, and elevated serum lipids.

The invention relates to a cyclic peptide capable of reducing insulin, not increasing blood sugar but properly reducing blood sugar at the same time, and belongs to the technical field of biological pharmacy. The bifunctional cyclic peptide is obtained through in-vitro modification on the basis of an original linear short peptide COX52-69; the effects of two seemingly contradictory aspects are achieved; namely, the effect of inhibiting insulin secretion but not increasing blood sugar at the same time is achieved; blood sugar is reduced; and the mechanism of the bifunctional cyclic peptide is possibly to improve the sensitivity of tissue to insulin. It is called as a bifunctional peptide. The bifunctional peptide can be used for congenital insulinemia, insulin tolerance, hyperinsulinemia of obese people and the like; literatures report that insulin increase is the reason of obesity; but people cannot lose weight through a method of reducing insulin all the time; and because blood sugar is increased after insulin is reduced, hyperglycemia is more adverse to health. The cyclic peptide realizes the function that the blood sugar is not increased but is reduced while insulin is reduced, so that a new medicine is developed for treating obesity; and the medicine not only can be administrated by injection, but also can be conveniently administrated by oral administration. The convenience of using the medicine is greatly improved.