The invention discloses a high-voltage plasma discharge power supply device based on STM32 adjustable voltage, include the main circuit, Button and display circuit, A control circuit and a power supply circuit, the main circuit includes a rectifier bridge, Filter capacitor, inverter circuit, Hall voltage sensor, Hall current sensor and boost transformer, A control circuit includes a STM 32 minimumsystem, download circuit, serial communication circuit, An overcurrent protection circuit, a remote start-stop control circuit, a soft start control circuit, a SPI FLASH circuit, an overheat protection circuit, an undervoltage protection circuit, a PWM driving circuit, an ADC conversion circuit, a voltage-current conversion circuit and a frequency detection circuit, and a key and display circuitcomprise a key, an indicator light and an LCD display screen; The invention can improve the production efficiency, the processing quality and the production safety, meanwhile, the circuit of the invention adds a plurality of protective circuits to increase the reliability.