The invention relates to an isolation type double-path output DC-DC power supply and industrial control equipment, the isolation type double-path output DC-DC power supply comprises an input filter capacitor, an enabling divider resistor, a DC-DC main circuit, an output filter capacitor, a voltage feedback resistor and an isolation rectification circuit, the DC-DC main circuit is provided with a first inductor which plays a role of a transformer, and the first inductor is connected with a decoupling device. According to the isolated dual-path output DC-DC power supply, the decoupling device is additionally arranged on the basis of an existing isolated dual-path output DC-DC power supply circuit, and the decoupling device is arranged to be connected with the first inductor which plays a role of a transformer in the DC-DC main circuit; therefore, when the first inductor L1 in the DC-DC main circuit presents leakage inductance due to heavy load or short circuit of one path of isolation loop voltage F5V output by the first inductor L1, the decoupling device is used for supplementing leakage inductance of a certain magnitude, the voltage output by the DC-DC power supply circuit is ensured to be stable, and the condition of mutual crosstalk of two paths of output voltage is avoided.