The invention discloses a novel super-soft flame-retardant knitting yarn which comprises core wires, a shielding layer and knitting yarn, each core wire comprises a conductor core and an inner insulating layer wrapping the conductor core, the multiple core wires are stranded together to form a signal wire, the shielding layer and the knitting yarn are sequentially arranged outside the signal wire,the conductor core comprises a plurality of wires and a plurality of strands of reinforced fibers, and the plurality of wires and the plurality of strands of reinforced fibers are uniformly distributed and stranded together to form the conductor core; the invention further discloses a manufacturing method of the cable. The manufacturing method comprises the steps of preparing polyphenylene sulfide silk threads, wires, reinforcing fibers, shielding wires and reinforcing wire raw materials, twisting the conductor cores, wrapping the core wires, twisting the core wires, weaving the shielding layer and weaving the yarns. By arranging a specific structure and a corresponding manufacturing method, the strength and the flexibility of the core wire are enhanced while the wire is fully dispersed,a good heat insulation, flame retardance and shielding effect is achieved, the skin effect generated by signals or currents in wire transmission is effectively avoided, and the transmission capacity of the wire is enhanced.